Generic
Vonoprazan + Amoxicillin
1 brands available in the market
At a glance
This combination is indicated for the treatment of H. pylori infection in adults.
Description
14 days daily administration for morning, mid-day and night dosing each containing Vonoprazan 20 mg and Amoxicillin 500 mg.
Indications
- H. pylori infection
Therapeutic class
Anti H. pylori drugs
Pharmacological class
Potassium Competitive Acid Blocker + Antibiotic
Pharmacology
Vonoprazan inhibits H+, K+-ATPase in gastric parietal cells, blocking gastric acid production. Amoxicillin is an antibacterial drug.
Mechanism of action
Vonoprazan blocks gastric acid production, and amoxicillin destroys H. pylori bacteria.
Dosage
Adult Dose (Oral):
- Morning: 1 Vonoprazan 20 mg tablet & 2 Amoxicillin 500 mg capsules
- Midday: 2 Amoxicillin 500 mg capsules
- Night: 1 Vonoprazan 20 mg tablet & 2 Amoxicillin 500 mg capsules
- With or without food, for 14 days
Administration
- May be taken with or without food
- Use as directed by a physician
Missed dose
If you miss a dose, take it as soon as you remember; if almost time for next dose, skip it; do not double the dose.
Side effects
Common Side Effects:
- Diarrhea
- Abdominal pain
- Vulvovaginal candidiasis
- Nasopharyngitis
Precautions & warnings
- Serious and occasionally fatal hypersensitivity reactions (e.g., anaphylaxis) have been reported
- Discontinue at the first signs or symptoms of SCAR
- Evaluate if diarrhea occurs with Vonomax Duo
Contraindications
- Known hypersensitivity to Vonoprazan, Amoxicillin or any other beta-lactams, or any component of Vonomax Duo
- Rilpivirine-containing products
Drug interactions
- Strong or moderate CYP3A inducers: drug-drug interaction may occur
- Probenecid, Itraconazole, Allopurinol, Omeprazole, Saquinavir, Ritonavir, Etravirine & Rilpivirine
Food interactions
Food interactions are not significant.
Use in pregnancy
Use in Pregnancy: Based on findings from animal studies and observational studies in pregnant women with use of Clarithromycin, use of Vonomax Duo is not recommended in pregnant women.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Avoid breastfeeding during Vonomax Duo therapy.
Pediatric use
Safety and effectiveness not established in pediatric patients
Geriatric use
Caution required in elderly patients
Renal / hepatic impairment
Renal Impairment: Mild to moderate (eGFR 30-89 mL/min): no dose adjustment; severe (eGFR <30 mL/min): avoid
Hepatic Impairment: Mild: no dose adjustment; moderate to severe: avoid
Overdose effects
Symptoms: No information is available on accidental overdosage in humans.
Treatment: Contact a physician, poison control center, or emergency room.
Storage conditions
Store at below 30°C in a dry place protected from light. Keep out of reach of children.