৳ 500/unit
Pack: ৳ 3,500
৳ 500/unit
Pack: ৳ 3,500
At a glance
Generic Name: Abiraterone Acetate Dosage Form: Oral Tablet Therapeutic Class: Cytotoxic Chemotherapy
Indications
• Metastatic Castration-Resistant Prostate Cancer (mCRPC) • Metastatic High-Risk Castration-Sensitive Prostate Cancer (mCSPC)
Pharmacology
Abiraterone Acetate is converted to Abiraterone, which inhibits CYP17, reducing androgen production in the testes, adrenal glands and tumour tissues, thereby slowing prostate cancer growth.
Dosage
mCRPC: 1000 mg once daily + Prednisone 5 mg twice daily. mCSPC: 1000 mg once daily + Prednisone 5 mg once daily. Moderate hepatic impairment (Child-Pugh B): Start with 250 mg once daily.
Side effects
Fatigue, arthralgia, hypertension, nausea, oedema, hypokalaemia, hot flushes, diarrhoea, vomiting, upper respiratory tract infection, cough and headache.
Use in pregnancy
Not recommended during pregnancy. It may cause fetal harm.
Precautions & warnings
Monitor blood pressure, potassium levels, liver function (ALT, AST, bilirubin) and signs of adrenal insufficiency during treatment.
Overdose effects
There is no specific antidote. Stop treatment and provide supportive care with cardiac monitoring and liver function assessment.
Storage conditions
Store below 25°C. Protect from light and keep out of the reach of children.