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Memantine Hydrochloride is a medicine used in the treatment of Alzheimer's disease. It helps to slow down the progression of moderate to severe Alzheimer's by improving memory and thinking. This medicine works by blocking a chemical messenger involved in the transmission of nerve signals. Memantine Hydrochloride is taken by mouth with or without food. However, it is advised to take it at the same time each day to maintain a consistent level of medicine in the blood. If you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to your doctor. Remember to inform the doctor if you have a history of seizures, kidney disease, heart disease, or liver disease. Some common side effects of this medicine include headache, confusion, sleepiness, abnormal liver function tests, balance disorder and shortness of breath. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may cause diarrhea, so drink plenty of fluids to keep yourself hydrated. Memantine Hydrochloride is an N-methyl-D-aspartate (NMDA) receptor antagonist. Memory loss in Alzheimer’s disease is due to excessive production of glutamate (chemical messenger) in the brain which is mediated by NMDA receptors. Memantine Hydrochloride works by preventing the action of NMDA receptors and regulates the production of glutamate. involved in the transmission of nerve signals. This is how it prevents memory loss in Alzheimer’s disease.

• Alzheimer's disease

Memantine, a derivative of amantadine, is a noncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist. It affects transmission of glutamate, the primary excitatory neurotransmitter in the CNS. Glutamate may contribute to the pathogenesis of Alzheimer's disease by overstimulating various glutamate receptors resulting in excitotoxicity and neuronal cell death.

Adult Dose: Oral Moderate to severe dementia in Alzheimer's disease Adult: As hydrochloride: Initially, 5 mg daily in the morning for the 1st wk; increase dose wkly in steps of 5 mg. Max: 20 mg daily. Wait for at least 1 wk between dose changes. Doses >10 mg/day should be given in 2 divided doses. Suggested titration: 5 mg daily for >1 wk; 5 mg bid for >1 wk; 15 mg daily given in 5- and 10-mg separated doses for >1 wk; then 10 mg bid. Hepatic impairment Mild or moderate (Child Pugh A/B): No dosage adjustment required Severe (Child Pugh C): Caution Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation 5-29 Max: 10 mg daily. 30-49 10 mg daily (after initial dose of 5 mg daily), if well tolerated for at least 7 days, may increase to 20 mg daily.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Memantine Hydrochloride may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Memantine Hydrochloride, skip it and continue with your normal schedule. Do not double the dose.

Common: • Dizziness • Headache • Confusion • Sleepiness • Diarrhea • Abnormal liver function tests • Balance disorder (loss of balance) • Breathlessness • Pulmonary hypertension (high blood pressure) • Hypersensitivity

[UNSAFE] Memantine Hydrochloride may cause side effects which could affect your ability to drive. You have been prescribed Memantine Hydrochloride to slow down the progression of Alzheimer's disease. It is well tolerated and has lesser side effects as compared to other similar medicines. Be cautious while driving or doing anything that requires concentration until you know how Memantine Hydrochloride affects you. Inform your doctor if you have a history of seizures, kidney disease, heart disease, or liver disease. Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.

Hypersensitivity to memantine or components of the formulation. Severe renal impairment.

May increase effects of antimuscarinics and dopaminergics. May reduce effects of antipsychotics and barbiturates. May alter effects of dantrolene, baclofen. Reduced clearance with carbonic anhydrase inhibitors and sodium bicarbonate. Potentially Fatal: Increased risk of adverse effects with amantadine, dextromethorphan or ketamine.

[CAUTION] Caution is advised when consuming alcohol with Memantine Hydrochloride. Please consult your doctor.

[SAFE IF PRESCRIBED] Memantine Hydrochloride is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[CONSULT YOUR DOCTOR] Information regarding the use of Memantine Hydrochloride during breastfeeding is not available. Please consult your doctor.

[CAUTION] Memantine Hydrochloride should be used with caution in patients with severe kidney disease. Dose adjustment of Memantine Hydrochloride may be needed. Please consult your doctor. [CAUTION] Memantine Hydrochloride should be used with caution in patients with severe liver disease. Dose adjustment of Memantine Hydrochloride may be needed. Please consult your doctor. Limited information is available on the use of Memantine Hydrochloride in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.

Patient has history of epilepsy. In 2006 epilepsy stroke arrived since then his memory is reducing. Admenta 10 & oleptal DT tabs r prescribed. But medicines are less effective over the period of time of its use. Pls show pt 2 neurologist for clear opinion My mother is suffering from dementia and taking donep10 mg and admenta 10 mg. Kindly suggest if there is some way around to treat this. Is stem cell therapy useful? Brain simulation useful? Kindly help. Thanks, Lalit only experimental; no proven benefit so far Why the failure of Alzheimer's therapy now a days??? as the disese mechanisms are still not defined in absolute terms; still PATIENT is needed and is ongoing Sir, My father ( an advocate) has developed symptoms of Alzheimer recently and sometimes he takes medicines on his own. He gets weak and unable to walk after taking tablets. Is there any test which can tell which medicines that he took? He takes Ayurved, Allopath, Homeopathy all and does not listen to me. Kindly help Dear Sir Thank you for consulting with me. Alzheimer's disease is a difficult disease to handle since patient develops dementia or forgetfulness. There are no blood tests which can tell you which medicines he took. Please consult a neurologist/ Psychiatrist I am suffering from alzehimer. I forget things like where I put key in morning. Some small things which makes me to suffer from condolence. What is the reason and how can I cure it ? Alzheimer's have many reasons which may be genetic, vitamins deficiency, hormonal problems, alcohol, other drugs, age related and others. We need to investigate you for finding cause. I strongly advice consultation with psychiatrist. If you are from Mumbai, see me.There is no cure to Alzheimer's, but we can suppress symptoms. Looking at your age, I am very much sure you are not suffering from Alzheimer's!!!! G-DON tablet is for what disease what is composition of gdon tablet Starts interpreting with strange people Wants to roam around if he sees a vehicles,repeats the same things or questions.At public place becomes uncontrolled,wants to finish his food tea or coffee very fast,lack of sleep and roams inside house and checks every container what is there inside He is prescribed Aripiren 5, Nuhenz,Aricep10mg,Admenta 5 mg,qtripil 100 Patient seems to have a mood disorder with or without dementia. It is treated with the medicines mentioned above. If treatment is in effective, your doctor will further modify the dose. Please maintain a regular follow up. I suffered from inflammatory bowel disease https://www.1mg.com/otc/jiva-digestol-tablet-otc329948One ?one tablet morning & evening after taking food , use at least 1-2 months