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At a glance

Ibuprofen + Paracetamol is a combination medicine used for temporary relief of moderate to severe pain. It is effective in migraine, headache, backache, menstrual pain, dental pain, rheumatic and joint pain, muscular pain, cold and flu symptoms, sore throat and fever.

Indications
  • Migraine
  • Headache
  • Backache
  • Menstrual pain
  • Dental pain
  • Rheumatic and joint pain
  • Muscular pain
  • Cold and flu symptoms
  • Sore throat
  • Fever
Pharmacology

Paracetamol relieves pain by inhibiting central prostaglandin synthesis and modulating descending serotonergic pathways. Ibuprofen inhibits COX-1 and COX-2 enzymes to inhibit prostaglandin synthesis, reducing pain, inflammation and fever.

Dosage

Adult Dose (Oral):

  • Recommended dose: 1 x 200/500 mg tablet OR 2 x 125/250 mg tablets three times daily (every 8 hours)
  • Maximum: 2 x 200/500 mg tablets three times daily if needed
  • Leave at least 6 hours between doses
  • Do not exceed 3000 mg paracetamol and 1200 mg ibuprofen in 24 hours
Side effects

Common Side Effects:

  • Abdominal pain and discomfort
  • Vomiting
  • Diarrhea
  • Nausea
  • Dyspepsia
  • Hyperhidrosis
  • Increased serum creatinine and blood urea
  • Abnormal liver function tests
Use in pregnancy

Use in Pregnancy: Avoid in first 6 months of pregnancy; contraindicated in last 3 months.

Pregnancy Category: D — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Caution in patients with history of bronchial asthma or allergic disease
  • Caution in hypertension, mild-moderate CHF, SLE, G6PD deficiency, chronic malnutrition, anorexia, bulimia, cachexia, dehydration, hypovolemia
  • Monitor for GI bleeding regularly
  • Caution in elderly patients
Overdose effects

Overdose: Pallor, nausea, vomiting, abdominal pain, drowsiness, convulsions, hepatic or renal damage; treat with activated charcoal (within 1 hour) and N-acetylcysteine (up to 24 hours).

Storage conditions

Store below 30°C in a dry place, protected from light; keep out of reach of children.

Ibuprofen + Paracetamol — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.