৳ 1/unit
Pack: ৳ 1
৳ 1/unit
Pack: ৳ 1
At a glance
Acyclovir (Topical) is an antiviral cream used for the treatment of skin infections caused by herpes simplex virus (herpes labialis/cold sores). It prevents viral multiplication in skin cells and clears the infection.
Indications
Initial and recurrent labial herpes (cold sores/herpes labialis) and genital herpes simplex infections (treatment should begin as early as possible).
Pharmacology
Acyclovir is a synthetic purine derivative that exerts antiviral effects on Herpes simplex virus (HSV) and Varicella zoster virus by interfering with DNA synthesis and inhibiting viral replication. In herpes-infected cells, acyclovir's antiviral activity depends on intracellular conversion to acyclovir triphosphate. Acyclovir is converted to acyclovir monophosphate primarily via virus-coded thymidine kinase; the monophosphate is phosphorylated to diphosphate via cellular guanylate kinase and then to triphosphate via other cellular enzymes, which is the pharmacologically active form. Percutaneous absorption of acyclovir is minimal following topical application to intact skin.
Dosage
Adults and children over 12 years:
- Apply cream to lesions 5 times daily (approximately every 4 hours)
- Continue treatment for 5-10 days
- Initiate treatment as early as possible after onset of signs and symptoms
Side effects
Common side effects (<1%):
- Dry lips
- Desquamation (skin peeling)
- Dry skin
- Cracked lips
- Burning sensation on skin
- Pruritus (itching)
- Flakiness of skin
- Stinging sensation on skin
Use in pregnancy
Pregnancy Category: B. Use during pregnancy only if potential benefit justifies potential risk to the fetus.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Apply only to external aspects of lips and face
- Do not use in eyes, inside the mouth, or inside the nose
- Consult doctor if symptoms do not improve after 10 days
- Efficacy not established in immunocompromised patients
- May cause irritation or contact dermatitis at application site
Overdose effects
Topical overdose is unlikely; excessive application may cause skin irritation.
Storage conditions
Store at room temperature between 20°C-25°C.