Act-HIB

• Prevention of Haemophilus influenzae type b infection - meningitis, septicemia, cellulitis, arthritis

This vaccine contains the antigenic capsular polysaccharide of H. influenzae type b which induces antibody production. It is approved for use in children 2 months through 5 years of age and is given as a 4-dose series by intramuscular injection.

Child Dose (2 months-5 years):

• Primary series: 0.5 mL each at 2, 4, and 6 months (first dose may be given at 6 weeks)
• Booster: 0.5 mL at 15-18 months

6-12 months (previously unvaccinated):

• 2 injections 1 month apart, then booster in second year

1-5 years (previously unvaccinated):

• 1 dose

Common Side Effects:

• Irritability - 72.6%
• Drowsiness - 57.5%
• Tenderness - 46.3%
• Induration - 22.5%
• Fever - 20.1%
• Anorexia - 15.3%
• Diarrhea - 4.4%
• Injection site erythema/induration/pain/swelling

Use in Pregnancy: Not applicable (for children).

Precautions:

• Minor illnesses such as upper respiratory infection with or without low-grade fever are not contraindications
• H. influenzae type b disease may occur subsequent to vaccination and prior to onset of protective effects - medical supervision needed
• Immunosuppressive therapy may reduce immune response to vaccine

Overdose: Overdose is unlikely (given in prescribed doses).

Storage: Store at 2°C-8°C (refrigerator). Do not freeze.