৳ 350/unit
Pack: ৳ 350
৳ 350/unit
Pack: ৳ 350
At a glance
Esmolol Hydrochloride is a beta-1 selective adrenergic receptor blocker used for the short-term treatment of supraventricular tachycardia and perioperative tachycardia and hypertension.
Indications
- Supraventricular Tachycardia: Control of ventricular rate in SVT including atrial fibrillation and atrial flutter.
- Noncompensatory Sinus Tachycardia: Control of heart rate.
- Perioperative Tachycardia and Hypertension: Control of heart rate and blood pressure during and after surgery.
Pharmacology
Esmolol Hydrochloride is a beta-1 selective (cardioselective) adrenergic receptor blocking agent with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilizing activity at therapeutic dosages. Its elimination half-life after intravenous infusion is approximately 9 minutes. It inhibits the beta 1 receptors located chiefly in cardiac muscle, but at higher doses it begins to inhibit beta 2 receptors located chiefly in the bronchial and vascular musculature.
Dosage
Adult Dose (IV):
- SVT or Noncompensatory Sinus Tachycardia: Optional loading dose: 500 mcg/kg over 1 minute, then 50 mcg/kg/min for 4 minutes; adjust as needed up to 200 mcg/kg/min.
- Perioperative Tachycardia and Hypertension: Loading dose: 500 mcg/kg over 1 minute (gradual) or 1 mg/kg over 30 seconds (immediate); then 50 mcg/kg/min (gradual) or 150 mcg/kg/min (immediate); adjust up to 200 (tachycardia) or 300 (hypertension) mcg/kg/min.
Side effects
Common Side Effects (>10%):
- Symptomatic hypotension (hyperhidrosis, dizziness)
- Asymptomatic hypotension
Other Side Effects:
- Nausea
- Infusion site reactions
Use in pregnancy
Use in Pregnancy: Category C. Animal studies have shown fetal harm. No adequate studies in pregnant women. Should be used only if potential benefit justifies potential risk to the fetus.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Risk of hypotension, bradycardia, and cardiac failure: Reduce or discontinue use.
- Risk of exacerbating reactive airway disease.
- Diabetes mellitus: Increases the effect of hypoglycemic agents and masks hypoglycemic tachycardia.
- Risk of unopposed alpha-agonism and severe hypertension in untreated pheochromocytoma.
- Risk of myocardial ischemia when abruptly discontinued in patients with coronary artery disease.
Overdose effects
Overdose: Overdose may cause severe hypotension, bradycardia, cardiac failure. In case of overdose, discontinue drug and provide supportive treatment.
Storage conditions
Storage: Keep below 25°C, away from light & moisture. Keep out of reach of children.