Albol DS400mg

Albendazole is a broad-spectrum anthelmintic effective against intestinal nematodes, cestodes, and tissue helminths. It exerts larvicidal, ovicidal, and vermicidal activities by inhibiting tubulin polymerization in parasites.

Indicated in infestations of Hookworm, Roundworm, Threadworm, Whipworm, Strongyloides, Tapeworm, Opisthorchis, Giardiasis, and Hydatid disease.

Anthelmintic

Benzimidazole Derivative

Albendazole blocks glucose uptake in susceptible helminths, depleting their energy levels. It inhibits parasite tubulin polymerization. It undergoes rapid first-pass metabolism to the active metabolite albendazole sulphoxide (half-life ~8.5 hours).

Binds to parasite tubulin to inhibit microtubule polymerization and disrupts glucose absorption, causing energy depletion and parasite death.

Adults & Children >2 years: 400 mg as a single dose for common worms. For strongyloidiasis or taeniasis: 400 mg daily for 3 consecutive days. Children 1-2 years: 200 mg single dose. Hydatid disease (>60 kg): 400 mg twice daily for 28 days.

For oral use. Tablets may be chewed, swallowed with water, or crushed. Administration with fatty meals increases systemic absorption.

Take as soon as remembered. Skip if it is close to the next scheduled dose. Do not take a double dose.

Gastrointestinal discomfort, headache, dizziness, elevated liver enzymes, reversible alopecia, and rarely blood disorders (leukopenia, pancytopenia).

Perform blood counts and liver function tests before and during treatment cycles in Hydatid disease. Exclude pregnancy prior to initiating therapy.

Contraindicated during pregnancy or in women suspected to be pregnant, and in patients with known hypersensitivity to benzimidazoles.

Plasma levels of the active metabolite may be increased by dexamethasone, praziquantel, or cimetidine.

Systemic absorption is significantly increased when taken with fatty foods.

FDA Pregnancy Category C. Contraindicated in pregnancy and women planning pregnancy.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Excretion in human milk is unknown. Exercise caution when administering to nursing mothers.

Not recommended in children under 1 year. Dosage is reduced to 200 mg for children aged 1–2 years.

No dosage adjustment needed, but use with standard precautions.

No dose adjustment required in renal or hepatic failure, but monitor LFTs during prolonged therapy.

Symptomatic treatment and supportive care should be initiated upon accidental overdose.

Store in a dry place below 30°C, protected from light and heat. Keep out of reach of children.

Albendazole (C12H15N3O2S)

Question: What is Albendazole used for? Answer: Albendazole is a broad-spectrum anthelmintic indicated for intestinal and tissue helminth infections including hookworm, roundworm, threadworm, whipworm, tapeworm, giardiasis, and hydatid disease. Question: What is the recommended dosage for general worm infestations? Answer: For adults and children over 2 years, a single dose of 400 mg is recommended for common intestinal worms. For children aged 1-2 years, a single dose of 200 mg (5 ml suspension) is recommended. Question: Can Albendazole be taken during pregnancy? Answer: No, Albendazole is contraindicated during pregnancy (Pregnancy Category C) or in women suspected to be pregnant. Question: Should Albendazole be taken with food? Answer: Administering Albendazole with a fatty meal significantly increases its absorption and systemic efficacy, especially for tissue-invading infections like Hydatid disease.