৳ 25.08/unit
Pack: ৳ 250.80
৳ 25.08/unit
Pack: ৳ 250.80
At a glance
Almotriptan is a selective serotonin receptor agonist used for the acute treatment of migraine attacks. It constricts blood vessels in the brain and relieves migraine headaches.
Indications
Acute headache phase of migraine attacks with or without aura; treatment of migraine in adolescents aged 12-17 years.
Pharmacology
Almotriptan is a selective and potent serotonin (5-HT1B/1D) receptor agonist. It binds to specific serotonin receptors on meningeal arteries, inhibiting the release of vasoactive peptides and causing arterial constriction. It has limited effect on arteries supplying blood to the brain and little effect on cardiac and pulmonary vessels.
Dosage
Adults: 6.25-12.5 mg (12.5 mg is more effective) as a single dose at onset of migraine; may repeat after 2 hours if needed; maximum 25 mg/day.
Adolescents (12-17 years): 6.25-12.5 mg as a single dose at onset of migraine; may repeat after 2 hours if needed; maximum 25 mg/day.
Hepatic impairment: Starting dose 6.25 mg; maximum 12.5 mg/24 hours.
Severe renal impairment: Starting dose 6.25 mg; maximum 12.5 mg/24 hours.
Side effects
Common side effects: Dizziness, dry mouth, flushing (warmth in face, ears, neck, and trunk), jaw pain, nausea, neck pain, sleepiness, throat pain, weakness, paresthesia (tingling or pricking sensation).
Serious (rare): Myocardial infarction, severe allergic reactions, serotonin syndrome (when used with SSRIs or SNRIs).
Use in pregnancy
Pregnancy Category: C. Animal studies have shown harmful effects on the fetus; human studies are limited. Use only if clearly needed with medical advice.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Cardiac risk: Ischemic heart disease, coronary artery vasospasm, angina pectoris, silent ischemia, Prinzmetal's angina – contraindicated.
- Hypertension: Uncontrolled hypertension – contraindicated; monitor blood pressure regularly.
- Driving: May cause drowsiness and dizziness; do not drive or operate machinery.
- Mood changes: May cause mood changes or depression; regular monitoring required.
- Pregnancy & breastfeeding: Consult your doctor.
- Sulfonamide allergy: Caution in patients with history.
Overdose effects
Overdose symptoms: excessive increase in blood pressure, dizziness, nausea, vomiting. Treatment: symptomatic and supportive measures.
Storage conditions
Store below 30°C in a cool and dry place, protected from light. Do not freeze. Keep out of reach of children.