৳ 20/unit
Pack: ৳ 200
৳ 20/unit
Pack: ৳ 200
At a glance
Memantine + Donepezil is used for the treatment of moderate to severe dementia of the Alzheimer's type. Memantine acts as an NMDA receptor antagonist and Donepezil acts as an acetylcholinesterase inhibitor.
Indications
- Moderate to severe dementia of the Alzheimer's type (patients stabilized on donepezil 10 mg once daily)
Pharmacology
Memantine reduces glutamate-induced excitotoxicity by blocking NMDA receptors; Donepezil enhances cholinergic neurotransmission by inhibiting acetylcholine breakdown.
Dosage
Adult Dose (Oral):
- On donepezil 10 mg only: Initial 7/10 mg in the evening; increase by 7 mg weekly to maintenance 28/10 mg
- On memantine (28 mg ER) + donepezil 10 mg: 28/10 mg in the evening
- Severe renal impairment: Maintenance 14/10 mg in the evening
Side effects
Common Side Effects (≥5%):
- Headache
- Diarrhea
- Dizziness
- Anorexia
- Nausea, vomiting
- Ecchymosis
Use in pregnancy
Use in Pregnancy: No adequate data in pregnant women; use only if clearly needed.
Precautions & warnings
- May exaggerate succinylcholine-type muscle relaxation during anesthesia
- Vagotonic effects on sinoatrial and atrioventricular nodes (bradycardia or heart block)
- Monitor for gastrointestinal bleeding
- May cause bladder outflow obstruction
- Elevated urine pH decreases memantine elimination
Overdose effects
No specific overdose information available; symptomatic and supportive treatment.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.