৳ 0.55/unit
Pack: ৳ 0.55
৳ 0.55/unit
Pack: ৳ 0.55
At a glance
Amitriptyline Hydrochloride is a tricyclic antidepressant used for depression, neuropathic pain, migraine, tension-type headache and nocturnal enuresis in children.
Indications
Depression; neuropathic pain (chronic nerve-related pain); migraine prevention; tension-type headache; nocturnal enuresis (bedwetting) in children 6 years and older.
Pharmacology
Amitriptyline Hydrochloride is a dibenzocycloheptadine tricyclic antidepressant. It blocks neuronal reuptake of norepinephrine and serotonin in the CNS, increasing their synaptic concentration. This improves mood and treats depression. It also relieves neuropathic pain by stopping pain signal transmission from nerves to the brain.
Dosage
Adults (Depression): Initial 25-50 mg at night (single dose) or divided doses; gradually increase to 150-200 mg/day (up to 300 mg/day in hospital). Elderly & debilitated: 10-25 mg at night; increase gradually. Children (6-10 years, enuresis): 10-20 mg/day (at night); 11-16 years: 25-50 mg/day (at night); max 3 months. Neuropathic pain/Migraine prevention: 10-25 mg at night; gradually increase to 50-75 mg/day.
Side effects
Common side effects: Dry mouth, drowsiness, dizziness, constipation, difficulty in urination, increased heart rate, orthostatic hypotension, weight gain, blurred vision, nasal congestion, increased sweating, fatigue, increased appetite. Rare: Aggressive behavior, agitation, confusion, memory impairment, sexual dysfunction.
Use in pregnancy
Pregnancy Category: C. Animal studies have shown harmful effects on the fetus; human studies are limited. Use only if clearly needed with medical advice.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
It may take 4-6 weeks to start working; continue as prescribed. Do not stop suddenly without consulting your doctor (withdrawal symptoms may occur). Caution while driving (drowsiness). Avoid alcohol completely (excessive drowsiness). Monitor weight and appetite (weight gain may occur). Inform doctor if you experience suicidal thoughts or mood changes. Caution in liver disease. Caution during pregnancy and lactation.
Overdose effects
Overdose symptoms: cardiac arrhythmias, severe hypotension, seizures, coma, confusion, diminished reflexes. Treatment: symptomatic and supportive measures, ECG monitoring.
Storage conditions
Store below 30C in a cool and dry place, protected from light and moisture. Keep out of reach of children.