৳ 1/unit
Pack: ৳ 1
৳ 1/unit
Pack: ৳ 1
At a glance
Amiloride Hydrochloride + Hydrochlorothiazide is a combination diuretic used for the treatment of hypertension (high blood pressure). It removes excess water and salt from the body and maintains potassium balance.
Indications
Hypertension (high blood pressure).
Pharmacology
Amiloride is a potassium-sparing diuretic that blocks sodium channels in the distal convoluted tubule and collecting duct, reducing sodium reabsorption and decreasing potassium secretion. Hydrochlorothiazide inhibits the Na+-Cl- symporter in the distal convoluted tubule, increasing sodium and chloride excretion, reducing plasma volume and lowering blood pressure. This combination effectively lowers blood pressure and amiloride prevents hydrochlorothiazide-induced potassium loss.
Dosage
Adults: 1 tablet daily (50 mg Hydrochlorothiazide + 5 mg Amiloride) in the morning with food, or as directed by the physician.
Maximum dose: Usually not more than 2 tablets daily.
Side effects
Common side effects: Nausea, vomiting, diarrhea, headache, weakness, muscle cramps, increased uric acid levels, electrolyte imbalance, glucose intolerance.
Serious (rare): Hyperkalemia (high blood potassium), hyponatremia, hypokalemia, kidney damage, allergic reactions.
Use in pregnancy
Generally considered safe during pregnancy (Pregnancy Category: B). Animal studies have shown low or no adverse effects on the fetus; human studies are limited.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution during pregnancy and lactation
- Caution while driving (may cause dizziness and drowsiness)
- Avoid alcohol (may increase dizziness)
- Caution in kidney and liver disease; not recommended in severe kidney disease
- Regular monitoring of electrolytes required
Overdose effects
Overdose symptoms: electrolyte depletion (hypokalemia, hyponatremia, hypochloremia), dehydration, excessive hypotension. Treatment: symptomatic and supportive measures.
Storage conditions
Store below 30°C in a cool and dry place, protected from light. Keep out of reach of children.