Amoclav 125/31

• Respiratory tract infections (pneumonia, bronchitis)
• Ear, nose and sinus infections (otitis media, sinusitis)
• Urinary tract infections
• Skin and soft tissue infections
• Dental infections
• Abdominal infections
• Septicemia
• Bone and joint infections

Amoxicillin is a broad-spectrum penicillin antibiotic that binds to penicillin-binding proteins and inhibits the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall, resulting in bacterial lysis.

Clavulanic Acid is a beta-lactamase inhibitor that binds to and inactivates beta-lactamase enzymes produced by certain bacteria. These enzymes typically inactivate amoxicillin by hydrolyzing its beta-lactam ring. Clavulanic Acid prevents this resistance mechanism, extending amoxicillin's antibacterial spectrum to include many bacteria normally resistant to amoxicillin and other penicillins.

Adult Oral Dosage:

• Mild-moderate infections: 375 mg (250/125) every 8 hours OR 625 mg (500/125) every 12 hours
• Severe infections: 625 mg (500/125) every 8 hours OR 1000 mg (875/125) every 12 hours
• Maximum dose: up to 6000 mg amoxicillin/600 mg clavulanic acid daily

Adult IV Dosage:

• 1.2 g (1000/200 mg) every 6-8 hours
• Severe infections: 1.2 g every 4-6 hours
• Maximum dose: up to 7.2 g daily

Pediatric Oral Dosage:

• Suspension (125/31.25 or 250/62.5 mg/5 mL): 20-40 mg/kg/day (amoxicillin) every 8 hours, max 1500 mg/day
• Suspension (200/28.5 or 400/57 mg/5 mL): 25-45 mg/kg/day (amoxicillin) every 12 hours, max 1750 mg/day

Pediatric IV Dosage:

• Children (3 months-12 years): 30 mg/kg every 6-8 hours
• Children (0-3 months): 30 mg/kg every 8 hours (every 12 hours in perinatal period and premature infants)

Renal Dose: Dose adjustment needed in severe renal impairment.

• Vomiting
• Nausea
• Diarrhea
• Abdominal pain
• Loss of appetite
• Skin rash
• Allergic reactions

[SAFE IF PRESCRIBED] Amoxicillin + Clavulanic Acid is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects on the developing baby; however, there are limited human studies. Use under doctor's supervision.

Important Precautions:

• Inform your doctor if allergic to penicillin or cephalosporin antibiotics - serious anaphylactic reactions may occur
• Complete the full course - do not stop even if you feel better
• Stop and inform your doctor immediately if you develop allergic reactions (rash, swelling of face/throat/tongue, breathing difficulties)
• Inform your doctor if you notice bloody stools or develop abdominal cramps
• Caution in infectious mononucleosis
• Caution in kidney and liver disease
• Do not use leftover medicine for any future infection
• Take with food and plenty of fluids

Amoxicillin: Overdose may cause nausea, vomiting, diarrhea, and electrolyte imbalance. Can be removed by hemodialysis.

Clavulanic Acid: Overdose may cause gastrointestinal problems.

Store below 30°C, away from light and moisture. Keep out of reach of children. Prepared suspension should be used within 7 days and stored in the refrigerator.