Anasone

• Leprosy
• Acne vulgaris (patients 12 years and older)
• Dermatitis herpetiformis

Dapsone has both anti-inflammatory and antimicrobial properties. Anti-inflammatory effects include inhibition of neutrophil myeloperoxidase and eosinophil peroxidase activity, suppression of hypochlorous acid production, scavenging of reactive oxygen species, suppression of neutrophil activity, and inhibition of chemoattractant-induced signal transduction. Antimicrobial activity is by inhibition of bacterial dihydropteroate synthase in the folic acid metabolic pathway.

Adult - Leprosy: 100 mg once daily (in combination with other antileprosy drugs).

Adult - Dermatitis Herpetiformis: 50 mg once daily, titrate up to 300 mg daily as needed.

Child: 2 mg/kg (max 100 mg/day) or 4 mg/kg (max 200 mg) once weekly.

Topical Gel (Acne): 7.5% gel once daily or 5% gel twice daily, apply a thin layer (pea-sized amount) to clean, dry skin.

Common (Topical): Oiliness/peeling, dryness, and erythema at the application site.

Common (Oral): Rash, fever.

Serious: Methemoglobinemia, hemolysis (in G6PD deficient patients), agranulocytosis, hepatitis.

Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Discontinue if signs of methemoglobinemia occur; risk of hemolysis in G6PD deficient patients; monitor blood cell counts with long-term use; caution in patients with sulfa hypersensitivity.

Overdose may lead to methemoglobinemia and hemolysis. Seek medical attention.

Store at or below 30°C temperature. Keep away from light and moisture. Keep out of reach of children.