৳ 10,000/unit
Pack: ৳ 10,000
৳ 10,000/unit
Pack: ৳ 10,000
At a glance
Anidulafungin is an antifungal medication used in the treatment of severe fungal infections. It kills the fungi that cause infections by preventing them from making their protective covering.
Indications
- Candidemia
- Other forms of Candida infections (intra-abdominal abscess, peritonitis)
- Esophageal candidiasis
Pharmacology
Anidulafungin is a semi-synthetic echinocandin antifungal that inhibits 1,3-beta-D-glucan synthesis, an essential component of the fungal cell walls. It inhibits glucan synthase, an enzyme present in fungal but not mammalian cells.
It has been shown to have in vitro activity against many Aspergillus spp and Candida spp (including C. albicans, C. glabrata, C. parapsilosis, C. tropicalis, C. krusei).
Dosage
| Infection Type | Adult Dose | Pediatric Dose (1 month+) |
|---|---|---|
| Candidemia & Other Candida Infections | 200 mg loading dose on Day 1, followed by 100 mg once daily (for at least 14 days after last positive culture) | 3 mg/kg (max 200 mg) loading dose on Day 1, followed by 1.5 mg/kg (max 100 mg) once daily (for at least 14 days after last positive culture) |
| Esophageal Candidiasis | 100 mg loading dose on Day 1, followed by 50 mg once daily (minimum 14 days and at least 7 days after symptom resolution) | Not approved |
Special Instructions:
- Infusion rate: Do not exceed 1.1 mg/min
- No dose adjustment needed in renal or hepatic impairment
- No dose adjustment needed based on gender, weight, ethnicity, HIV positivity, or elderly
Side effects
- Hypokalemia (decreased potassium level in blood)
- Nausea
- Vomiting
- Diarrhea
- Dyspepsia
- Abdominal pain
- Pyrexia/Fever
- Insomnia
- Hypotension
- Headache
- Anemia
- Thrombocytopenia
- Injection site reactions (pain, swelling, redness)
Use in pregnancy
[SAFE IF PRESCRIBED] Anidulafungin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Serious Precautions:
- Monitor liver function regularly - risk of abnormal liver tests, hepatitis, hepatic failure
- Anaphylaxis including shock may occur - seek immediate medical attention if allergic symptoms occur
- Infusion-related reactions (rash, urticaria, flushing, pruritus, bronchospasm, dyspnea, hypotension) - do not exceed infusion rate of 1.1 mg/min
- Not approved in pediatric patients younger than 1 month (risk of polysorbate 80 toxicity)
- Hereditary Fructose Intolerance (HFI) - check history in pediatric patients
- Consult your doctor if pregnant, planning pregnancy or breastfeeding
- Complete the full course - do not stop even if you feel better
Overdose effects
In clinical trials, a single 400 mg dose was inadvertently administered as a loading dose. No clinical adverse events were reported. No specific antidote; symptomatic treatment required.
Storage conditions
Vial (unreconstituted): Store in a refrigerator (2-8°C). Do not freeze.
Reconstituted solution (in vial): Store at up to 25°C for up to 24 hours. Do not freeze.
Infusion solution: Store at up to 25°C for up to 48 hours. Do not freeze.