Ariprex 10

• Schizophrenia
• Bipolar disorder (manic or mixed episodes)
• Major depressive disorder (adjunctive treatment)
• Irritability associated with autistic disorder
• Agitation associated with schizophrenia or bipolar mania

Schizophrenia:

• Adults: Initial: 10-15 mg/day, Recommended: 10-15 mg/day, Maximum: 30 mg/day
• Adolescents (13-17 years): Initial: 2 mg/day → 5 mg/day after 2 days → 10 mg/day after 2 more days, Maximum: 30 mg/day

Bipolar Mania:

• Adults (Monotherapy): Initial: 15 mg/day, Maximum: 30 mg/day
• Adults (Adjunct to lithium/valproate): Initial: 10-15 mg/day, Recommended: 15 mg/day, Maximum: 30 mg/day
• Pediatric (10-17 years): Initial: 2 mg/day → 5 mg/day after 2 days → 10 mg/day after 2 more days, Maximum: 30 mg/day

Major Depressive Disorder (Adjunct):

• Initial: 2-5 mg/day, Recommended: 5-10 mg/day, Maximum: 15 mg/day

Irritability in Autistic Disorder (6-17 years):

• Initial: 2 mg/day → 5 mg/day (within 1 week), Maximum: 15 mg/day

Tourette Disorder (6-18 years):

• <50 kg: 2 mg/day → 5 mg/day after 2 days → up to 10 mg/day if needed
• ≥50 kg: 2 mg/day (2 days) → 5 mg/day (5 days) → 10 mg/day (Day 8), Maximum: 20 mg/day

Special Populations: No dose adjustment needed in renal impairment. No dose adjustment likely needed in hepatic impairment.

• Akathisia (inability to stay still)
• Anxiety
• Blurred vision
• Constipation
• Dizziness
• Fatigue
• Headache
• Increased saliva production
• Indigestion
• Insomnia (difficulty in sleeping)
• Nausea
• Parkinsonism
• Restlessness
• Sleepiness
• Tremor
• Vomiting
• Extrapyramidal disorder
• Sedation
• Pyrexia
• Decreased appetite

Serious Precautions:

• Increased incidence of cerebrovascular adverse events (stroke, TIA, including fatalities) in elderly patients with dementia-related psychosis
• Increased risk of suicidality in children, adolescents, and young adults with major depressive disorder
• Tardive dyskinesia - discontinue if clinically appropriate
• Metabolic changes: hyperglycemia/diabetes mellitus, dyslipidemia, and body weight gain - monitor blood sugar and cholesterol regularly
• Orthostatic hypotension - caution in patients with known cardiovascular or cerebrovascular disease
• Seizures - use cautiously in patients with a history of seizures
• Caution when operating machinery - may cause dizziness and sleepiness
• Do not stop suddenly - may worsen symptoms
• Caution during pregnancy and lactation - animal studies have shown harmful effects on the developing baby
• Inform your doctor if you notice sudden mood changes, unusual movements or develop suicidal thoughts