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Arnis 50

24mg+26mgOTC
Generic: Sacubitril + Valsartan

৳ 35/unit

Pack: ৳ 350

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At a glance

Sacubitril + Valsartan is an ARNI (angiotensin receptor neprilysin inhibitor) used to reduce the risk of cardiovascular death and hospitalization in patients with chronic heart failure (NYHA class II-IV). It relaxes blood vessels and makes it easier for the heart to pump blood.

Indications
  • Chronic heart failure (NYHA class II-IV) – reduce cardiovascular death and hospitalization
  • Pediatric heart failure (≥1 year)
Pharmacology

Sacubitril's active metabolite LBQ657 inhibits neprilysin, preventing degradation of natriuretic peptides (ANP, BNP), leading to vasodilation, natriuresis, and reduced plasma volume. Valsartan blocks angiotensin II type-1 receptors, inhibiting vasoconstriction and aldosterone secretion. This dual action reduces hemodynamic burden in heart failure.

Dosage

Adult Heart Failure:

  • Starting: 49/51 mg twice daily
  • Target maintenance: Double to 97/103 mg twice daily after 2-4 weeks (as tolerated)
  • Reduced starting (not on ACEi/ARB, low dose, severe renal, moderate hepatic): 24/26 mg twice daily

Pediatric (≥1 year):

  • <40 kg: 1.6→2.3→3.1 mg/kg
  • 40-<50 kg: 24/26→49/51→49/51 mg
  • ≥50 kg: 49/51→72/78→97/103 mg
Side effects

Common Side Effects:

  • Angioedema
  • Hypotension
  • Impaired renal function
  • Hyperkalemia
  • Cough
  • Dizziness
  • Orthostatic hypotension
Use in pregnancy

Use in Pregnancy: Unsafe during pregnancy; definite evidence of risk to the developing baby; use only in life-threatening situations; consult your doctor.

Pregnancy Category: D — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Do not use in patients with history of angioedema
  • Do not use with ACE inhibitors (36-hour washout)
  • Do not use with aliskiren in diabetic patients
  • Not recommended in severe hepatic impairment (Child-Pugh C)
  • Unsafe in pregnancy; avoid in lactation
Overdose effects

Overdose is most likely to cause hypotension; provide symptomatic treatment; unlikely to be removed by hemodialysis due to high protein binding.

Storage conditions

Store below 30°C in a dry place, protected from moisture; keep out of reach of children.

Sacubitril + Valsartan — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.