৳ 220/unit
Pack: ৳ 220
৳ 220/unit
Pack: ৳ 220
At a glance
Artemether + Lumefantrine is a combination antimalarial used for the treatment of acute, uncomplicated malaria caused by Plasmodium falciparum. It is effective against chloroquine-resistant parasites.
Indications
- Acute, uncomplicated malaria caused by Plasmodium falciparum
- Mixed malaria infections including P. falciparum
- Effective against chloroquine-resistant malaria parasites
- Active against blood stages of P. vivax
Pharmacology
This preparation contains Artemether and Lumefantrine in a 1:6 ratio. Artemether is an artemisinin derivative. Lumefantrine is a synthetic racemic fluorine mixture belonging to the aryl amino alcohol family (like quinine, mefloquine, halofantrine).
Both components act in the malarial parasite's food vacuoles. Lumefantrine interferes with the polymerization process, while Artemether generates reactive metabolites through interaction between the peroxide bridge and heme iron. Both also inhibit nucleic acid-protein synthesis in the parasite.
Dosage
Weight-based Dosing:
- ≥35 kg: 6-dose course (total 24 tablets) - 4 tablets initially, 4 after 8 hours, then 4 tablets twice daily for 2 days
- 25-35 kg: 3 tablets per dose (total 18 tablets)
- 15-25 kg: 2 tablets per dose (total 12 tablets)
- 5-15 kg: 1 tablet per dose (total 6 tablets)
Each tablet contains 20 mg artemether and 120 mg lumefantrine. Take with food (especially fatty food or milk) to enhance absorption.
Side effects
- Headache
- Dizziness
- Loss of appetite
- Weakness
- Muscle and joint pain
- Nausea and vomiting
- Abdominal pain
- Diarrhea
- Rash
- Cough
- Abnormal gait
Use in pregnancy
[CONSULT YOUR DOCTOR] Contraindicated in the first trimester. May be used in the second and third trimesters only if necessary and under medical supervision.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Serious Precautions:
- Not indicated for malaria prophylaxis.
- Not evaluated for cerebral malaria or severe malaria complications.
- Contraindicated in the first trimester of pregnancy.
- Avoid use during breastfeeding - discontinue breastfeeding for 28 days after last dose.
- Use with caution in patients at risk of QT prolongation.
- May cause dizziness - use caution while driving or operating machinery.
- If vomiting occurs within 1 hour, take another dose.
- Inform your doctor if you have kidney, liver, or heart disease.
Overdose effects
In case of overdose, provide symptomatic and supportive treatment. Monitor ECG and blood potassium levels.
Storage conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.