৳ 35/unit
Pack: ৳ 350
৳ 35/unit
Pack: ৳ 350
At a glance
Iguratimod tablet is used for the treatment of rheumatoid arthritis (RA) and other rheumatic and autoimmune conditions.
Indications
- Rheumatoid arthritis (RA)
- Sjögren's syndrome
- Ankylosing spondylitis
- Systemic lupus erythematosus (SLE)
Pharmacology
Iguratimod acts on both T and B lymphocytes to suppress immune response. It inhibits production of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6 and IL-17 which contribute to inflammation. It promotes bone formation while inhibiting differentiation and activity of bone-resorbing osteoclasts, demonstrating osteoprotective activity.
Dosage
Adult Dose (Oral):
- Rheumatoid Arthritis: 25 mg twice daily (morning and evening) after meals
- Some cases: Start with 25 mg once daily for 1-2 weeks to improve tolerance, then increase to twice daily
- Mild renal/hepatic impairment: Dose adjustment usually not required (caution needed)
- Often used alone or in combination with methotrexate or other DMARDs
Child Dose: Safety and efficacy not established
Side effects
Common Side Effects:
- Nausea
- Stomach pain
- Diarrhea
- Indigestion
- Headache
- Dizziness
- Tiredness
- Mild increase in liver enzymes (ALT, AST)
- Mild decrease in blood counts
Use in pregnancy
Use in Pregnancy: Contraindicated; teratogenic risk and not enough safety data; effective contraception required during treatment and for some time after discontinuation.
Precautions & warnings
Precautions:
- Liver toxicity: May cause elevated liver enzymes (ALT, AST); regular LFTs required (baseline, then periodically); stop if significant hepatotoxicity occurs
- Bone marrow suppression: Can cause leukopenia, neutropenia, anemia, or thrombocytopenia; monitor CBC regularly
- Renal impairment: Use with caution; monitor renal function
- Infections: Immunomodulator may increase risk of infections; avoid use in active infections
- Gastrointestinal effects: Take after meals to reduce GI upset
Overdose effects
No information on overdose; do not exceed the recommended dose.
Storage conditions
Keep below 30°C temperature, away from light & moisture; keep out of reach of children.