Atrium25mg/2.5ml

• Skeletal muscle relaxation during general anesthesia
• Facilitation of endotracheal intubation
• Controlled ventilation during surgical procedures
• Facilitation of mechanical ventilation in ICU patients

Adult Dosage:

• Initial bolus: 0.3-0.6 mg/kg (depending on duration of full block required); intubation can usually be accomplished within 90 seconds at 0.5-0.6 mg/kg
• Maintenance dose: 0.1-0.2 mg/kg as required
• Continuous infusion: 0.3-0.6 mg/kg/hour during long surgical procedures
• Cardiovascular disease patients: 0.3-0.4 mg/kg, administered slowly over 60 seconds
• Long-term ICU infusion: Average 11-13 mcg/kg/min (range: 4.5-29.5)

Pediatric (>1 month): Same dosage as adults

Elderly: Standard dosage can be used, but starting at the lower end of the range is recommended

Other: Continuous monitoring of neuromuscular function is recommended during long-term ICU use. Dosage for obese patients should be based on ideal body weight.

Very Common (≥1/10):

• Skin flushing

Common (≥1/100 to <1/10):

• Skin rash, itching
• Hypotension (mild, transient)
• Injection site reactions (pain, swelling, redness)

Uncommon/Rare:

• Anaphylactic/anaphylactoid reactions (including shock, circulatory failure)
• Prolonged muscle paralysis (in overdose)

ICU patients (rare):

• Seizures (in patients with predisposing conditions)
• Muscle weakness and myopathy (after prolonged administration, often with corticosteroids)

Serious Precautions:

• Atracurium should be used only by those skilled in airway management and respiratory support.
• Severe anaphylactic reactions have been reported; immediate availability of emergency treatment is required.
• Extreme caution in patients with myasthenia gravis or other neuromuscular diseases.
• Caution in patients with severe electrolyte disorders, respiratory insufficiency, or asthma.
• Continuous monitoring of neuromuscular transmission is recommended during long-term ICU use.