ATV 40

• Primary hyperlipidemia, heterozygous familial hypercholesterolemia, dysbetalipoproteinemia, hypertriglyceridemia
• Homozygous familial hypercholesterolemia (HoFH) in patients aged 10 years and older
• Reduction of MI, stroke, and revascularization in adults with multiple CHD risk factors or type 2 diabetes

Adults:

• Primary hyperlipidemia, dysbetalipoproteinemia, hypertriglyceridemia: 10-20 mg once daily; may increase to 40 mg.
• Heterozygous familial hypercholesterolemia: 10 mg initial; may increase to 20-40 mg.
• Cardiovascular event prevention: 10-20 mg daily (40 mg in older adults).

Pediatric (10-17 years - HeFH):

• Initial dose: 10 mg daily.
• Maximum dose: 20 mg daily (increase at ≥4-week intervals).

Dose Modifications for Drug Interactions:

• Clarithromycin, itraconazole, saquinavir+ritonavir, darunavir+ritonavir: Do not exceed 20 mg daily.
• Nelfinavir: Do not exceed 40 mg daily.

• Common (≥5%): Nasopharyngitis, diarrhea, arthralgia, pain in extremity, urinary tract infection
• Other: Headache, constipation, muscle pain, nausea, indigestion
• Serious (rare): Myopathy/rhabdomyolysis, hepatic injury, diabetes, increased blood glucose

Serious Precautions:

• Report any muscle pain, tenderness, or weakness during treatment.
• Do not use during pregnancy or breastfeeding.
• Do not use if you have active liver disease or unexplained liver enzyme elevations.
• Monitor blood sugar in diabetic patients (atorvastatin may slightly increase blood glucose).
• If signs of serious liver injury (abdominal pain, dark urine, yellow skin/eyes) occur, discontinue and consult your doctor.
• Use caution in patients with substantial alcohol consumption, history of liver disease, or hypothyroidism.