৳ 16/unit
Pack: ৳ 80
৳ 16/unit
Pack: ৳ 80
At a glance
Phenobarbitone Sodium injection is a barbiturate used for the treatment and prevention of epilepsy (seizures). It controls seizures by suppressing abnormal and excessive activity of nerve cells in the brain and also has sedative and hypnotic properties.
Indications
- Epilepsy/Seizures
- Emergency control of acute convulsive episodes (status epilepticus)
- Preoperative sedation
- Insomnia (short-term)
Pharmacology
Phenobarbitone is a short-acting barbiturate that depresses the sensory cortex, reduces motor activity, and produces drowsiness, sedation, and hypnosis. It acts on GABAA receptors, increasing synaptic inhibition and elevating seizure threshold.
Dosage
Adult Dose (Parenteral):
- Status epilepticus/Acute seizures: 200-600 mg OR 15-18 mg/kg IV loading (25-60 mg/min); may repeat at 20-min intervals; not to exceed 30 mg/kg
- Insomnia (hypnotic): 100-320 mg; do not administer for >2 weeks
- Preoperative sedation (IM): 100-200 mg (60-90 min pre-op)
- Hepatic impairment: Reduce dose; Severe: Contraindicated
Pediatric Dose (Parenteral):
- Status epilepticus/Acute seizures: 100-400 mg OR 15-20 mg/kg IV (max 2 mg/kg/min; max 1000 mg/dose)
- Preoperative sedation (IM): 16-100 mg (60-90 min pre-op)
- Preoperative sedation (IV): 1-3 mg/kg
Side effects
Common Side Effects:
- Drowsiness
- Nausea
- Diarrhea
- Hyperactivity
- Depression
- Confusion
- Decreased blood pressure
- Fatigue
- Headache
- Dizziness
- Constipation
- Excitement
- Hangover
Use in pregnancy
Use in Pregnancy: Unsafe during pregnancy; definite evidence of risk to the developing baby; doctor may prescribe in life-threatening situations if benefits outweigh risks.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May be habit-forming with long-term use
- May affect driving ability; do not drive if drowsy or dizzy
- Do not stop suddenly (may increase seizure frequency)
- Inform doctor if skin rash with fever occurs
- Inform doctor if joint pain or history of bone disease
- Caution in pregnancy and lactation
Overdose effects
Overdose: CNS and respiratory depression; 1 gram dose produces serious poisoning; 2-10 grams can cause death. Treatment: Supportive; immediate hospitalization required.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.