Barri 2

Baricitinib is a Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis. It helps decrease pain, tenderness and swelling in the joints by reducing inflammation. It also helps slow the progression of bone and joint damage. Baricitinib may be prescribed alone or in combination with another drug. The tablets can be taken with or without food, but it is best to take them at the same time each day. Your dose will depend on your condition and what other medicines you are taking. You should use it as your doctor tells you to. Do not stop taking this medicine unless your doctor tells you to because your condition could get worse. The most common side effects of Baricitinib include throat and nose infections, nausea and viral infection. You may also get cold sores, feel sick or have symptoms of a cold like stuffy nose, sneezing and sore throat. There are other less common side effects, some of them serious, including blood clots and tears in the stomach or intestine wall. These need urgent medical attention. If you have concerns regarding side effects, talk to your doctor. You may need blood tests before you are given this medicine and you should not start taking it if you have any kind of infection. Make sure you talk to your doctor before starting treatment if you have, or have ever had, tuberculosis, shingles, kidney or liver disease, hepatitis B or C, or blood clots in your legs or lungs. Baricitinib can make you more likely to get infections or may worsen any current infections so avoid contact with people who have things you might catch (e.g., chickenpox, measles or flu). This medicine is not suitable for children under 18 years old and you should not use it if you're pregnant or breastfeeding, unless your doctor feels the benefit is greater than the risk. Your doctor may need to examine you on a regular basis. Baricitinib is Janus kinase inhibitor. It works by blocking the action of the enzyme, Janus kinase. This decreases inflammation and joint damage in rheumatoid arthritis.

• Rheumatoid arthritis

Janus kinases (JAKs) pathways inhibitor; JAK consists of a group of intracellular tyrosine kinases that transmit signals from cytokine or growth factor-receptor interactions on the cellular membrane to influence cellular processes of hematopoieses and immune cell function Within the signaling pathway, JAKs phosphorylate and activate signal transducers and activators of transcription (STATs), which modulate intracellular activity including gene expression; baricitinib modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs

Adult Dose: Rheumatoid Arthritis Indicated for adults with moderately to severely active rheumatoid arthritis (RA) who have had an inadequate response to one or more tumor necrosis factor (TNF) antagonist therapies May be used as monotherapy or in combination with methotrexate or other nonbiologic disease-modifying antirheumatic drugs (DMARDs) 2 mg PO qDay

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Baricitinib may be taken with or without food, but it is better to take it at a fixed time.

Common: • Nausea • Upper respiratory tract infection

[SAFE] Baricitinib does not usually affect your ability to drive. Baricitinib is used alone or in combination with methotrexate for the treatment of rheumatoid arthritis that did not improve with other anti-rheumatic drugs. It may take 3 to 6 months to feel the maximum effect of this medication. Keep taking it as prescribed. Your doctor may get regular blood tests done to monitor your liver function, kidney function, blood counts or cholesterol level. Baricitinib can make it a bit harder for people to fight off infections. Inform your doctor if you have symptoms of an infection such as fever, chills, cough, and muscle aches. Your doctor may get TB (tuberculosis) skin test and a chest X-ray before starting treatment with this medication. Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.

Avoid use of live vaccines; update immunizations in agreement with current immunization guidelines before initiating Coadministration with strong OAT3 inhibitors may increase baricitinib systemic exposure

[SAFE] Consuming alcohol with Baricitinib does not cause any harmful side effects.

[CONSULT YOUR DOCTOR] Baricitinib is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[CONSULT YOUR DOCTOR] Baricitinib is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[UNSAFE] Baricitinib is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor. [SAFE IF PRESCRIBED] Baricitinib is safe to use in patients with liver disease. No dose adjustment of Baricitinib is recommended. Baricitinib may not be recommended in patients with severe liver disease due to lack of information and research. Therefore, it is important to consult the doctor.

Rheumatoid arthritis diseases attack Rheumatoid arthritis diseases tablet for this please consult rheumatologist for the same I have joint pain in my rt wrist since 6 yrs. What are the possible reasons? It may be Tenosynovitis, or Rheumatoid arthritis or any other type of arthritis Sir/Ma'am, I feel pain in the heel of both the legs especially when I get up from the bed in the morning. After walking couple of steps, it goes away. there is no bone problem reported in the Xray report. Please guide me what could be the reason? This is the test for rheumatoid arthritis What is gatheya. What is it solution It is supposed to be Rheumatoid Arthritis Please suggest me medicines list to recover with rheumatoid arthritis https://www.1mg.com/otc/pain-away-tablet-otc333737One ?one tablet morning & evening after taking food , use at least 1-2 months All bone are comptly stif and she couldn't move any were looks like rheumatoid arthritishave u been evaluated for it Severe Joint pain in left hand wrist, elbow, shoulder and neck joint. Took some TEST and reports attached. Provided tablets are not killing the pain. Kindly help and guide us in right way. Attached Anti CCT TEST repory Looks like a case of rheumatoid arthritis.Kindly consult a rheumatologist asap Pain.in right shoulder.RA factor negative.3yrs suffering. Take folitrax7.5mg tab and hqtor ,folvitetab ,hifennac.is it suitable or any sideeffect Where else is the pain. Just pain in shoukfer is not rheumatoid arthritis.