Benazin 12.5
Rx- Generic:
- Tetrabenazine
- Company:
- Renata Limited
- Dosage form:
- Tablet
- Pack size:
- Strip (10 Tablet)
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৳ 20/unit
Pack: ৳ 200
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- ৳ 20
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At a glance
Tetrabenazine is a VMAT2 inhibitor used for the treatment of chorea associated with Huntington's disease. It reduces involuntary movements by depleting monoamine stores in synaptic vesicles.
Indications
- Chorea associated with Huntington's disease
Dosage
Adult Dose (Oral):
- Start (Week 1): 12.5 mg/day
- Week 2: 25 mg/day (12.5 mg twice daily)
- Titrate by 12.5 mg weekly to tolerated dose
- 37.5-50 mg/day: 3 divided doses (max single dose 25 mg)
- >50 mg/day: CYP2D6 genotyping required; Poor metabolizers: max 50 mg/day (single 25 mg); Extensive/intermediate: max 100 mg/day (single 37.5 mg)
- Elderly: Start 12.5 mg/day, increase gradually
Side effects
Common Side Effects (>10%):
- Sedation/somnolence, fatigue
- Insomnia, depression
- Akathisia, anxiety
- Nausea
Serious (Rare):
- Neuroleptic malignant syndrome (fever, muscle rigidity, confusion)
- Suicidal thoughts
- Pneumonia
Precautions & warnings
- Do not use in hepatic impairment
- Do not use in actively suicidal or untreated/undertreated depression
- May affect driving ability (somnolence, dizziness)
- Do not stop abruptly (may worsen symptoms)
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.