Benazin 25

Tetrabenazine is a prescription medicine used to treat Huntington's disease, a condition in which nerve cells in the brain breakdown over time, thus deteriorating the person’s physical and mental abilities. It also helps to relieve uncontrollable and jerky movements of the body. Tetrabenazine should be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. It is important that this medication is not stopped suddenly without talking to your doctor as it may worsen your symptoms. However, discontinue this medicine immediately if you experience neuroleptic malignant syndrome, characterized by fever, muscle rigidity and altered consciousness or seizures. Some common side effects of this medicine include nausea, insomnia(difficulty sleeping), anxiety, fatigue, akathisia (restlessness and inability to stay still) and depression. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts while taking this medicine. Tetrabenazine works by depleting the stores of certain chemical messengers in the brain that helps in controlling body movements.

• Huntington's disease

Reversibly inhibits human vesicular monoamine transporter type 2 (VMAT2), resulting in decreased uptake of monoamines (eg, dopamine, serotonin, norepinephrine, histamine) into synaptic vesicles and depletion of monoamine stores from nerve terminals This effect is similar to reserpine, but with less peripheral activity and is shorter-acting

Adult Dose: Oral Huntington Disease Indicated for treatment of chorea associated with Huntington’s disease Adult: Individualize and slowly titrate dosage over several weeks to identify a dose that reduces chorea and is well tolerated Total daily dose up to 50 mg/day 12.5 mg PO qDay initially; after 1 week, the dose should be increased to 12.5 mg q12hr Maintenance: Titrate slowly by weekly intervals of 12.5 mg/day to identify dose that reduces chorea and is tolerated If daily dose is 37.5 to 50 mg/day, administer in divided doses q8hr Elderly: Initially 12.5 mg daily, increased gradually. Total Daily dose >50 mg/day If >50 mg/day is required, test and genotype to determine if poor or extensive metabolizers of CYP2D6; not to exceed 100 mg/day or 37.5 mg/dose Moderate to severe tardive dyskinesia Adult: Initially 12.5 mg daily increased gradually according to response. Hepatic impairment Contraindicated; it is not possible to adjust the dose to ensure safe use Child Dose: Safety and efficacy not established

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tetrabenazine may be taken with or without food, but it is better to take it at a fixed time.

Common: • Nausea • Insomnia (difficulty in sleeping) • Anxiety • Fatigue • Sleepiness • Akathisia (inability to stay still) • Depression

[UNSAFE] Tetrabenazine may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. You have been prescribed Tetrabenazine to help control movement disorders such as in Huntington’s disease. Be cautious while driving or doing anything that requires concentration as Tetrabenazine can cause dizziness and sleepiness. Inform your doctor if you experience symptoms such as high fever, sweating, muscle stiffness, and faster breathing. These may be due to a rare side effect known as the neuroleptic malignant syndrome. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior. Do not stop taking Tetrabenazine without talking to your doctor first as it may cause worsening of symptoms.

Hypersensitivity. Lactation. Hepatic impairment. Patients who are actively suicidal, or who have untreated or inadequately treated depression.

Tetrabenazine should not be given with or within 14 days of discontinuation of MAOI therapy. Blocks action of reserpine. Decreases effects of levodopa and worsen parkinsonism. Increased risk of extrapyramidal side effects when given with amantadine, metoclopramide, antipsychotics.

[UNSAFE] Tetrabenazine may cause excessive drowsiness with alcohol.

[CONSULT YOUR DOCTOR] Tetrabenazine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Tetrabenazine is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Tetrabenazine in patients with kidney disease. Please consult your doctor. However, caution is advised in these patients. [UNSAFE] Tetrabenazine is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

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