৳ 1,200/unit
Pack: ৳ 1,200
৳ 1,200/unit
Pack: ৳ 1,200
At a glance
Bendamustine is an antineoplastic alkylating agent used in the treatment of chronic lymphocytic leukemia (CLL), non-Hodgkin lymphoma (NHL), and multiple myeloma. It creates crosslinks in DNA and RNA of cancer cells, stopping their growth and multiplication.
Indications
- Chronic Lymphocytic Leukemia (CLL)
- Non-Hodgkin Lymphoma (NHL) - Indolent B-cell NHL progressed during or within 6 months of rituximab-containing therapy
- Multiple myeloma
Pharmacology
Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. As an alkylating agent, it causes intra- and inter-strand crosslinks between DNA bases, disrupting DNA replication and RNA transcription, leading to disruption of nucleic acid function. It is active against both active and quiescent cells.
Dosage
Chronic Lymphocytic Leukemia (CLL): 100 mg/m² IV infusion (30-60 min) on Days 1 and 2 of a 28-day cycle, up to 6 cycles.
Severe toxicity: Reduce to 50 mg/m² on Days 1 and 2; if recurs, reduce to 25 mg/m².
Multiple Myeloma: 120-150 mg/m² IV infusion (30-60 min) on Days 1 and 2 of a 28-day cycle. Prednisone 60 mg/m² may be given on Days 1-4.
Non-Hodgkin Lymphoma (NHL): 120 mg/m² IV infusion (30-60 min) on Days 1 and 2 of a 21-day cycle, up to 8 cycles.
Severe toxicity: Reduce to 90 mg/m² on Days 1 and 2; if recurs, reduce to 60 mg/m².
Hepatic impairment: Mild: Caution; Moderate: Reduce dose by 30%; Severe: Not recommended.
Renal impairment (CrCl <40 mL/min): Not recommended.
Side effects
Common side effects:
Anemia (low red blood cells), leukopenia (low white blood cells), neutropenia, thrombocytopenia (low platelets), lymphopenia, infection, fatigue, nausea, vomiting, fever, diarrhea, constipation, anorexia, weight decrease, rash, stomatitis (mouth inflammation), cough, headache.
Serious: Malignant and pre-malignant disease, severe hematological toxicity, cardiotoxicity.
Use in pregnancy
Unsafe during pregnancy (Category D). Positive evidence of human fetal risk. May be used in life-threatening situations if benefits outweigh risks.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in mild-to-moderate hepatic and renal impairment.
- Do not use during pregnancy and lactation (Category D).
- Increased risk of infection; monitor CBC, kidney, liver, and cardiac function regularly.
- Use effective contraception during and after treatment.
- Avoid driving or activities requiring concentration until you know how it affects you.
Overdose effects
Symptoms: Cardiotoxicity, thrombocytopenia. Management: Bone marrow transplantation and transfusions may be performed. Dialyzable to a small extent.
Storage conditions
Store below 25°C prior to reconstitution. Protect from light.