Benkinson 62.550mg+12.5mg
Rx- Generic:
- Levodopa + Benserazide
- Company:
- Incepta Pharmaceuticals Ltd.
- Dosage form:
- Capsule
- Pack size:
- Strip (10 Capsule)
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৳ 8/unit
Pack: ৳ 80
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At a glance
Levodopa + Benserazide is used in the treatment of Parkinson's disease. Levodopa is a dopamine precursor that crosses the blood-brain barrier and is converted to dopamine in the brain. Benserazide is a peripheral decarboxylase inhibitor that reduces peripheral metabolism of levodopa, allowing more levodopa to reach the brain.
Indications
- Parkinson's disease - Immediate Release capsule: all forms except drug-induced Parkinsonism
- Parkinson's disease - Controlled Release capsule: patients with motor fluctuations, especially peak dose dyskinesia and end of dose deterioration and for better control of nocturnal symptoms
Dosage
Immediate Release IR Capsule:
- Patients not receiving levodopa: Early stage: 50+12.5 62.5 mg, 1-2 times/day; gradually increase by 62.5 mg every 3-4 days
- Adult: 50+12.5 62.5 mg, 3-4 times/day OR Advanced stage: 100+25 125 mg, 3 times/day
- Maintenance: 100+25 125 mg, up to 3-6 times/day
- Previous levodopa monotherapy: Initiate with 10-15% of previous dose
- Previous other levodopa/dopa decarboxylase combination: Withdraw previous therapy for 12 hours, start 50+12.5 62.5 mg, 3-4 times/day
Controlled Release CR Capsule:
- Patients not receiving levodopa: 100+25 125 mg, 3 times/day; maximum 6 capsules/day
- Previous levodopa-benserazide IR: Substitute every 100 mg levodopa with 1 CR capsule; increase every 2-3 days
Side effects
Common Side Effects:
- Anxiety, decreased appetite
- Arrhythmia
- Depression
- Diarrhea
- Hallucinations
- Movement disorders dyskinesia
- Nausea
- Postural hypotension
- Sleep disorders
- Altered taste
- Vomiting
- Leucopenia
Precautions & warnings
- Reduce dose if dyskinesia occurs early
- Caution with orthostatic hypotension
- Caution in psychiatric illness, diabetes, cardiovascular disease, peptic ulcer, glaucoma, pheochromocytoma
- Caution in Cushing's syndrome, endocrine disorders, hyperthyroidism, osteomalacia
- May activate malignant melanoma - do not use in suspicious lesions or history of melanoma
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.