Bestron

• Moderate to severe vasomotor symptoms associated with menopause (hot flashes)
• Prevention of postmenopausal osteoporosis

Conjugated Estrogens and Bazedoxifene function by binding to and activating estrogen receptors (ER) α and β. Bazedoxifene is an estrogen agonist / antagonist that acts as an agonist in some estrogen-sensitive tissues and an antagonist in others (e.g. uterus).

Dosage: 1 tablet once daily, without regard to meals. Tablets should be swallowed whole.

Women taking this for prevention of postmenopausal osteoporosis should add supplemental calcium and/or vitamin-D to their diet if daily intake is inadequate.

Common Side Effects:

• High blood pressure
• Blood clots
• Liver problems
• Thyroid problems
• Fluid retention
• Hypocalcemia
• Dementia
• Breast lumps
• Unusual vaginal bleeding
• Severe headache
• Muscle spasms
• Weakness and fatigue
• Nausea
• Diarrhea
• Throat pain
• Dizziness

Pregnancy Category X. Must not be used in women who are or may become pregnant.

• Estrogen therapy should not be used for the prevention of cardiovascular disease or dementia.
• There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens.
• Do not use in women with undiagnosed abnormal uterine bleeding, breast cancer history, estrogen-dependent neoplasia, active DVT/PE, arterial thromboembolic disease, hepatic impairment, or thrombophilic disorders.

Overdose symptoms: nausea, vomiting, breast tenderness, dizziness, abdominal pain, fatigue; withdrawal bleeding may occur. No specific antidote; treatment should be symptomatic.

Do not store above 30°C. Keep away from light. After opening foil pouch, product must be used within 60 days. Keep out of reach of children.