Beviprex HFA

• Chronic obstructive pulmonary disease (COPD): including chronic bronchitis and/or emphysema

Glycopyrronium is a long-acting muscarinic antagonist (LAMA) and Formoterol is a long-acting β₂-adrenergic agonist (LABA) with a rapid onset of action. Glycopyrronium has similar affinity to the subtypes of muscarinic receptors M1 to M5. In the airways, it exhibits pharmacological effects through inhibition of the M3 receptor at the smooth muscle leading to bronchodilation. Formoterol causes direct relaxation of airway smooth muscle as a consequence of the increase in cyclic AMP through activation of adenylyl cyclase.

Adult Dose:

• 2 puffs twice daily, in the morning and in the evening

Severe Renal Impairment:

• Should be used only if potential benefit outweighs the risk

* Use as directed by the registered physician

Common Side Effects:

• Cough
• Urinary tract infection
• Dry mouth
• Headache
• Tremor
• Nervousness
• Increased blood pressure
• Chest pain
• Irregular heartbeat
• Muscle spasm
• Urinary retention

Use in Pregnancy: No data on use in pregnant women. Use only if potential benefit justifies potential risk to the fetus.

Precautions:

• Should not be used with additional LABA-containing medicine (risk of overdose)
• Not indicated for acute bronchospasm
• If paradoxical bronchospasm occurs, discontinue
• Use with caution in cardiovascular disorders
• Use with caution in narrow-angle glaucoma, prostatic hyperplasia

Overdose: Formoterol overdose may cause angina, hypertension/hypotension, tachycardia, arrhythmias, hypokalemia, hyperglycemia. Symptomatic treatment should be given.

Storage: Do not store above 30°C. Do not expose to temperatures higher than 50°C. Do not pierce the pressurized container.