Bexitrol F

• Asthma: where use of a combination product is appropriate - patients not adequately controlled with inhaled corticosteroids and 'as needed' short-acting β₂-agonist, or patients already adequately controlled on both.
• COPD: Regular treatment of chronic obstructive pulmonary disease.

Salmeterol Xinafoate is a selective long-acting (12-hour) beta-2-adrenoceptor agonist with a long side chain that binds to the exo-site of the receptor. Fluticasone Propionate given by inhalation at recommended doses has a potent glucocorticoid anti-inflammatory action within the lungs, resulting in reduced symptoms and exacerbations of asthma.

Inhaler (Adults and 12+ years):

• 2 puffs of 25 µg + 50 µg twice daily
• 2 puffs of 25 µg + 125 µg twice daily
• 2 puffs of 25 µg + 250 µg twice daily

Children (4-12 years):

• 2 puffs of 25 µg + 50 µg twice daily

Inhalation Capsule (Asthma):

• 50 µg + 100 µg or 50 µg + 250 µg twice daily

Inhalation Capsule (COPD):

• 50 µg + 250 µg twice daily

* Use as directed by the registered physician

Salmeterol-related side effects:

• Tremor
• Palpitations
• Headache
• Cardiac arrhythmia
• Muscle cramps

Fluticasone-related side effects:

• Hoarseness
• Candidiasis of mouth and throat
• Hypersensitivity reactions

Use in Pregnancy: Use during pregnancy only if the expected benefit to the mother is greater than any possible risk to the fetus or child.

Precautions:

• Do not use in acute asthma attacks (fast-acting bronchodilator needed).
• Seek medical advice if asthma symptoms remain uncontrolled or worsen.
• Paradoxical bronchospasm may occur - use bronchodilator immediately and discontinue.
• COPD patients: increased reporting of pneumonia - remain vigilant.
• Systemic effects (Cushing's syndrome, adrenal suppression, growth retardation) may occur with high doses long-term.

Overdose:

• Salmeterol: Seizures, angina, hypertension/hypotension, tachycardia, arrhythmias, hypokalemia, hyperglycemia.
• Fluticasone: Temporary suppression of adrenal function.

Storage: Pressurised canister - do not puncture, break or incinerate. Avoid direct sunlight or heat. Store below 30°C.