৳ 8/unit
Pack: ৳ 80
৳ 8/unit
Pack: ৳ 80
At a glance
Cilnidipine is a calcium channel blocker used for the treatment of hypertension (high blood pressure) and angina.
Indications
- Hypertension (high blood pressure)
- Angina (heart-related chest pain)
- End-organ protection in chronic kidney disease
Pharmacology
Cilnidipine is a dihydropyridine calcium-channel blocker. Cilnidipine binds to the dihydropyridine binding sites of the L-type voltage dependent calcium channel and inhibits Ca2+ influx across the cell membranes of vascular smooth muscle cells via this channel, consequently vascular smooth muscle is relaxed, causing vasodilation. Cilnidipine inhibits Ca2+ influx via N-type voltage dependent calcium channels in the sympathetic nerve cell membrane. Cilnidipine is considered to suppress the reflex increase in heart rate after blood pressure reduction.
Dosage
Adult Dose (Oral): 5-10 mg once daily; may increase to 20 mg once daily if necessary.
Elderly: May be more susceptible to hypotension, initiate with the lowest possible dose (5 mg).
Side effects
Common Side Effects:
- Fatigue
- Ankle or foot swelling (peripheral edema)
- Sleepiness
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Headache
- Nausea
- Dizziness
- Palpitations
- Abdominal pain
- GI disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Depression
Use in pregnancy
[CONSULT YOUR DOCTOR] Information regarding the use of Cilnidipine during pregnancy is not available. Should not be administered in pregnant women or women having possibilities of being pregnant. Please consult your doctor.
Precautions & warnings
- [UNSAFE] Cilnidipine may cause side effects which could affect your ability to drive.
- Take it at the same time every day to help you remember.
- Rise slowly if you have been sitting or lying down to avoid dizziness or fainting.
- To reduce ankle or foot swelling, raise your legs while sitting.
- Avoid driving or activities requiring mental focus until you know how it affects you.
- Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding.
- Do not stop suddenly; dosage should be gradually decreased under close observation.
Overdose effects
Information on Cilnidipine overdosage is not available. Consult a physician if overdose is suspected.
Storage conditions
Store below 30°C, protected from light and moisture. Keep out of reach of children.