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At a glance

Desogestrel is a progestin (progestogen-only pill or minipill) used for contraception. It prevents ovulation and thickens cervical mucus to block sperm penetration.

Indications
  • Contraception (progestogen-only pill)
Pharmacology

Desogestrel is a progestogen structurally related to levonorgestrel that has been shown to reliably inhibit ovulation. Most minipills work primarily by preventing the sperm cells from entering the womb but do not always prevent the egg cell from ripening, which is the primary action of combined pills. This pill is distinct from other mini-pills in having a dose that in most cases is high enough to prevent the egg cell from ripening, providing high contraceptive efficacy.

Dosage

Adult: 75 mcg once daily (at the same time, continuously without a break). Available in 28-day strips.

Side effects

Common: Irregular bleeding, amenorrhoea, headache, weight gain, breast pain, nausea, acne, mood changes, decreased libido.
Other: Vaginitis, dysmenorrhoea, ovarian cysts, vomiting, alopecia, fatigue.

Use in pregnancy

Desogestrel is highly unsafe during pregnancy. Studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Pregnancy Category: X — always consult a doctor before taking during pregnancy.

Precautions & warnings

Highly effective for preventing pregnancy (>99%). Suitable for smokers, women over 35, and breastfeeding mothers. May cause irregular, lighter, or absent periods. Caution in history of thromboembolism, liver disease, diabetes.

Overdose effects

Overdose may cause nausea, vomiting, and in young girls, slight vaginal bleeding. No serious deleterious effects have been reported.

Storage conditions

Store below 30°C.

Desogestrel — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.