Caloprid 2

Prucalopride is a prescription medicine used in the treatment of constipation. It increases the release of certain chemical that improves the movement of food inside the intestine and helps to increase gastric emptying of both liquid and solid. Prucalopride is taken with or without food in a dose and duration as advised by the doctor. The dose you're given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine. The most common side effects are headache, nausea, and abdominal pain. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. This medicine may cause diarrhea, so it is better to take plenty of fluids while taking this medicine as it may help to prevent dehydration. Before taking it, you should tell your doctor if you have any kidney or liver diseases so that your doctor can prescribe a suitable dose for you. You should avoid this medicine if you are suffering from bleeding ulcers of the stomach. Consult with your doctor if are pregnant or breastfeeding. Prucalopride indirectly stimulates the release of acetylcholine, a chemical messenger that can increase the motility of the intestine.

• Constipation

Prucalopride is a selective 5-HT4 receptor agonist w/ prokinetic effect. It stimulates peristaltic reflex, intestinal secretions, and GI motility.

Adult Dose: Oral Chronic idiopathic constipation Adult: 2 mg once daily. Elderly: Initially, 1 mg once daily, may increase to 2 mg once daily if necessary. Hepatic Impairment Severe (Child-Pugh Class C): Initially, 1 mg once daily, may increase to 2 mg once daily if necessary. Renal Dose: Severe (GFR <30 mL/min/1.73 m2): 1 mg once daily. Patient on dialysis: Contraindicated.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Prucalopride may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Prucalopride, skip it and continue with your normal schedule. Do not double the dose.

Common: • Headache • Nausea • Diarrhea • Abdominal pain

[UNSAFE] Prucalopride may cause side effects which could affect your ability to drive. Prucalopride may cause dizziness and tiredness, especially on the first day of treatment, and this may have an effect on driving and use of machines. Prucalopride helps treat chronic constipation and improve bowel movements, when laxatives have failed to provide adequate relief. It can be taken with or without food, at any time of the day. It may cause diarrhea. Drink plenty of water and inform your doctor if it bothers you. Inform your doctor if your constipation has not improved even after four weeks of taking this medication.

Intestinal obstruction or perforation, obstructive ileus, active severe inflammatory bowel conditions (e.g. Crohn’s disease, toxic megacolon/megarectum, and ulcerative colitis). Renal impairment requiring dialysis. Pregnancy and lactation.

May decrease serum concentration of contraceptives (i.e. oestrogens, progestins). May enhance adverse effect of levosulpiride. Increased serum concentration w/ P-glycoprotein/ABCB1 inhibitors. Reduced effect w/ atropine-like substance.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Prucalopride. Please consult your doctor.

[CONSULT YOUR DOCTOR] Information regarding the use of Prucalopride during pregnancy is not available. Please consult your doctor.

[CONSULT YOUR DOCTOR] Prucalopride is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CAUTION] Prucalopride should be used with caution in patients with severe kidney disease. Dose adjustment of Prucalopride may be needed. Please consult your doctor. [CAUTION] Prucalopride should be used with caution in patients with severe liver disease. Dose adjustment of Prucalopride may be needed. Please consult your doctor. Limited information is available on the use of Prucalopride in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.

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