৳ 15/unit
Pack: ৳ 150
৳ 15/unit
Pack: ৳ 150
At a glance
Bromelain + Trypsin is a combination enzyme preparation used in the treatment of inflammatory pains, soft tissue inflammation, and edema associated with trauma and surgery. It works by modulating multiple inflammatory signaling pathways to reduce swelling and pain.
Indications
- Inflammatory pains
- Soft tissue inflammation
- Edema associated with trauma and surgery
- Gynaecological conditions
- Breast engorgement
- Fractures
- Sprains
- Injuries
- Hemorrhoids
- Anal prolapse
Pharmacology
Bromelain is a proteolytic enzyme derived from pineapple (Ananas comosus) with anti-inflammatory, anti-edema, and fibrinolytic properties. Trypsin is a serine protease derived from the pancreas that modulates inflammatory signaling pathways. This combination inhibits major inflammatory transcription factors such as NF-κB, reducing pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and COX-2 levels. It also exhibits antioxidant effects that reduce inflammation-related tissue stress.
Dosage
Initial dose: 2 tablets 3 times daily before meals.
Maintenance dose: 1 tablet 3 times daily before meals.
Note: In clinical studies, postoperative patients received 2 tablets 4 times daily for up to 10 days. Dosage may vary based on patient condition and physician's advice.
Side effects
- Bromelain may cause diarrhea and stomach and intestinal discomfort.
- Gastrointestinal issues such as bloating, nausea may occur (rare).
Use in pregnancy
Adequate information on the safety of bromelain + trypsin combination during pregnancy is not available; consult your doctor before use during pregnancy.
Precautions & warnings
- Patients allergic to pineapple, latex, wheat, celery, carrot, fennel, cypress pollen, or grass pollen may have an allergic reaction to bromelain.
- Bromelain may increase the risk of bleeding during and after surgery; inform your doctor before surgery.
- Caution if taking blood thinners (warfarin, aspirin, clopidogrel).
Overdose effects
Overdose may cause diarrhea, nausea, abdominal cramps. Consult your doctor if overdose is suspected.
Storage conditions
Store in a cool and dry place, away from light and moisture, below 30°C. Keep out of reach of children.