৳ 200/unit
Pack: ৳ 200
৳ 200/unit
Pack: ৳ 200
At a glance
Carboprost is a synthetic prostaglandin analogue used to terminate pregnancy between 13-20 weeks of gestation and to control postpartum uterine bleeding. It stimulates uterine contractions and ensures placental hemostasis.
Indications
- Termination of pregnancy between 13-20 weeks of gestation (2nd trimester abortion)
- Postpartum uterine hemorrhage (refractory to conventional treatments)
Pharmacology
Carboprost tromethamine administered intramuscularly stimulates myometrial contractions in the gravid uterus similar to labor contractions at term. These contractions evacuate the products of conception from the uterus. Postpartum, myometrial contractions provide hemostasis at the placentation site. Carboprost also stimulates gastrointestinal smooth muscle (causing vomiting/diarrhea) and can elevate body temperature. Large doses can raise blood pressure by contracting vascular smooth muscle.
Dosage
Abortion (13-20 weeks): Initial dose: 250 mcg (1 mL) deep IM injection. Repeat 250 mcg every 1.5-3.5 hours based on uterine response. Optional test dose: 100 mcg (0.4 mL). May increase to 500 mcg (2 mL) if uterine contractility is inadequate. Maximum total dose: 12 mg. Maximum duration: 2 days.
Postpartum Uterine Hemorrhage: Initial dose: 250 mcg (1 mL) deep IM injection. Repeat 250 mcg every 15-90 minutes as needed. Maximum total dose: 2 mg (8 doses).
Note: For use in a hospital setting by trained medical personnel only.
Side effects
Common (smooth muscle contractile effects): Vomiting, nausea, diarrhea, pyrexia (fever), flushing (sense of warmth), headache, chills, cough, placental retention.
Other: Endometritis, retained placental fragments, excessive uterine bleeding (post-abortion complications), transient temperature increase, transient bronchoconstriction.
Large doses may raise blood pressure.
Use in pregnancy
Highly unsafe during pregnancy (used only for abortion). Animal and human studies have shown significant harmful effects to the developing baby.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Use only in a hospital setting by trained medical personnel with immediate intensive care and surgical facilities.
- Use with caution in patients with history of asthma, hypo- or hypertension, cardiovascular, renal or hepatic disease, anemia, jaundice, diabetes, epilepsy, and compromised (scarred) uteri.
- In patients with chorioamnionitis, the uterus may not respond to carboprost.
- Examine the cervix immediately post-abortion.
- Do not use during pregnancy (abortion/postpartum use only).
- Know your response before driving (may cause unconsciousness, dizziness, drowsiness).
Overdose effects
Overdose may cause severe uterine hyperstimulation, excessive uterine contractions, uterine rupture, severe vomiting/diarrhea, hypertension, bronchospasm, fever. Treatment: Supportive and symptomatic.
Storage conditions
Store at 2-8°C. Do not freeze. Keep away from light. Once the ampoule has been opened, use immediately.