৳ 8/unit
Pack: ৳ 112
৳ 8/unit
Pack: ৳ 112
At a glance
Trimetazidine Dihydrochloride is an anti-anginal medicine used for treating heart-related chest pain (angina). It prevents new attacks of angina but does not stop an acute attack once it has started.
Indications
- Angina (heart-related chest pain)
Pharmacology
Trimetazidine is the first 3-keto acyl CoA thiolase inhibitor (KAT), a metabolic anti-ischemic agent. It inhibits fatty acid pathway by inhibiting 3-keto acyl CoA thiolase enzyme and transfers oxygen to glucose pathway. Since glucose pathway is more efficient in producing energy, the same oxygen produces more energy and makes the heart more active.
Dosage
Adult Dose (Oral):
- Angina pectoris: 40-60 mg daily in 2-3 divided doses
- Modified-release tablet: 35 mg twice daily
- Renal impairment: CrCl 30-60: 20 mg twice daily; modified-release 35 mg once daily; CrCl <30: contraindicated
Side effects
Common Side Effects:
- Constipation
- Dizziness
- Headache
- Nausea
- Vomiting
- Weakness
- Abdominal pain
- Diarrhea
- Dyspepsia
- Rash
- Pruritus
- Urticaria
Use in pregnancy
Use in Pregnancy: Information not available; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May decrease alertness; do not drive
- Prevents new attacks of angina but does not stop an acute attack
- Does not affect heart rate or blood pressure at rest or during exercise
- Improves HbA1c and blood sugar levels in diabetes patients
- Avoid driving or using machinery if you feel dizzy
Overdose effects
Symptoms: Dizziness, headache, hypotension.
Treatment: Supportive care.
Storage conditions
Keep in a dry place away from light and heat. Keep out of reach of children.