৳ 10.04/unit
Pack: ৳ 100.40
৳ 10.04/unit
Pack: ৳ 100.40
At a glance
Clopidogrel is an antiplatelet medication used to prevent harmful blood clots, reducing the risk of heart attack and stroke.
Indications
- Acute Coronary Syndrome (ACS) - Unstable Angina/Non-ST-Elevation MI (NSTEMI)
- Acute ST-Elevation MI (STEMI)
- Recent MI, Recent Stroke, or Established Peripheral Arterial Disease
Pharmacology
Clopidogrel is a prodrug. It inhibits platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets. Dose-dependent inhibition of platelet aggregation can be seen 2 hours after single oral doses. Repeated doses of 75 mg per day inhibit ADP-induced platelet aggregation on the first day, and inhibition reaches steady state between Day 3 and Day 7.
Dosage
Adult Dose (Oral):
- Prophylaxis of thromboembolic disorders, Recent MI/Stroke/Peripheral Arterial Disease, Coronary Artery Disease: 75 mg once daily.
- Acute Coronary Syndrome (with loading dose): Initial 300 mg (loading dose), then 75 mg once daily (up to 12 months).
- STEMI (75 years): 75 mg once daily for 14 days (without loading dose).
Pediatric Dose: Safety and efficacy not established.
Side effects
Common Side Effects:
- Bleeding (bruising, nosebleeds, blood in urine/stool, heavy periods)
- Diarrhea
- Gastrointestinal discomfort
- Skin reactions
Rare Side Effects: Acquired hemophilia, anemia, angioedema, arthralgia, arthritis, bone marrow disorders, Thrombotic Thrombocytopenic Purpura (TTP).
Use in pregnancy
[SAFE IF PRESCRIBED] Clopidogrel is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. Pregnancy Category B.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- [SAFE] Clopidogrel does not usually affect your ability to drive.
- For best results, take it at the same time every day.
- Clopidogrel increases your risk of bleeding. Be careful while shaving, using sharp objects, or cutting fingernails or toenails.
- Do not discontinue without consulting your doctor (increases risk of heart attack/stroke).
- May need to be stopped temporarily before surgery or dental treatment (5 days prior).
- Reduced antiplatelet activity in CYP2C19 poor metabolizers or patients taking omeprazole/esomeprazole.
Overdose effects
Overdose following clopidogrel administration may lead to bleeding complications. Platelet transfusion may restore clotting ability.
Storage conditions
Keep below 30°C temperature in a dry place. Protected from light. Do not freeze. Keep out of reach of children.