Carplatin 450

Carboplatin is used in the treatment of ovarian cancer and small cell lung cancer. It shows its working by stopping or slowing down the growth of cancer cells. Carboplatin is given as an injection into veins under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Nausea, vomiting, fatigue, and increased liver enzyme are some common side effects of this medicine. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections or bleeding. Inform your doctor if you notice fever, sore throat, chills, unusual bleeding or bruising, and dark urine. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. You must inform your doctor if you experience allergic reactions with injection such as skin rash, itching, and trouble breathing. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Carboplatin is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells which stops their growth and multiplication.

• Ovarian cancer • Small cell lung cancer

Carboplatin is an alkylating agent which binds covalently to DNA. It modifies the cell cycle by interfering with DNA structure and function.

Adult Dose: Intravenous Small cell lung cancer; Advanced ovarian carcinoma Adult: IV As single agent in treatment-naive patients: 400 mg/m2; As single agent in previously treated patients: 360 mg/m2; W/ cyclophosphamide in treatment-naive patients: 300 mg/m2. Doses to be given not more frequently than every 4 wk. Adjust subsequent doses based on nadir of WBC and platelet counts. Hepatic Impairment Dose adjustment may not be necessary; not studied Child Dose: Solid tumor 300-600 mg/m² IV q4Weeks Sarcoma (bone/soft tissue) 400 mg/m²/day for 2 days every 21 days Brain tumor 175 mg/m² qWeek x 4 weeks with a 2 weeks recovery period between courses Bone marrow transplant preparative regimen 500 mg/m²/day x 3 days Retinoblastoma 1-2 mL subconjunctival injection of 10 mg/mL solution per dose Renal Dose: Renal impairment: CrCl (ml/min) >40 Recommended dose: 400 mg/m2. 20-39 Recommended dose: 250 mg/m2.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Carboplatin, please consult your doctor.

Common: • Nausea • Vomiting • Anemia (low number of red blood cells) • Fatigue • Low blood platelets • Increased liver enzymes • Decreased white blood cell count (neutrophils) • Stomatitis (Inflammation of the mouth) • Peripheral neuropathy (tingling and numbness of feet and hand) • Diarrhea

[UNSAFE] Carboplatin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. It is given as an injection into the veins under the supervision of a doctor.

Previous allergy; pregnancy, lactation; allergy to other platinum compounds; severe bone marrow depression; significant bleeding, aluminium containing needles and IV sets.

Increased risk of ototoxicity when used with aminoglycosides.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Carboplatin. Please consult your doctor.

[CONSULT YOUR DOCTOR] Carboplatin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] Carboplatin is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[CAUTION] Carboplatin should be used with caution in patients with kidney disease. Dose adjustment of Carboplatin may be needed. Please consult your doctor. Use of Carboplatin is not recommended in patients with severe kidney disease. Regular monitoring of kidney function tests may be advised while you are taking this medicine. [SAFE IF PRESCRIBED] Carboplatin is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Carboplatin may not be needed in these patients. Please consult your doctor.

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