৳ 24/unit
Pack: ৳ 240
৳ 24/unit
Pack: ৳ 240
At a glance
Irbesartan is an angiotensin II receptor antagonist used for the treatment of essential hypertension and renal disease in patients with hypertension and type 2 diabetes mellitus.
Indications
- Essential hypertension
- Treatment of renal disease in patients with hypertension and type 2 diabetes mellitus
Pharmacology
Irbesartan is an angiotensin II receptor antagonist that blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by binding to AT1 receptors. Irbesartan is mainly metabolised by CYP2C9 and to a lesser extent by glucuronidation. The pharmacokinetic of digoxin is not altered by coadministration of irbesartan, and the pharmacokinetic of irbesartan is not affected by hydrochlorothiazide.
Dosage
Adult Dose (Oral):
- Hypertension: 150 mg once daily; may increase to 300 mg once daily if needed
- Intravascular volume depletion: Initially, 75 mg once daily
- Elderly (>75 years): Initially, 75 mg once daily
- Diabetic nephropathy in Type 2 diabetes: Initially, 75-150 mg once daily; may increase to 300 mg once daily if needed
Child Dose (≥12 years): 150 mg/day initially; may increase to 300 mg/day
Renal Dose: Haemodialysis: 75 mg once daily initially; mild-to-severe renal impairment: no dosage adjustment necessary (unless hypovolemic)
Side effects
Common Side Effects:
- Dizziness
- Increased potassium level in blood
- Headache
- Fatigue
- Nausea
- Vomiting
Less Common: Anxiety, Nervousness, Belching, Heartburn, Stomach discomfort, Diarrhea, Muscle or bone pain, Unusual tiredness
Use in pregnancy
Use in Pregnancy: Unsafe; second and third trimesters may cause fetal or neonatal renal failure, fetal skull hypoplasia and fetal death; avoid in first trimester; discontinue as soon as pregnancy is diagnosed.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- It is not known whether Irbesartan alters ability to drive; do not drive if you experience symptoms affecting concentration and reaction
- May cause dizziness for first few days; rise slowly from sitting or lying position
- Intravascular volume depletion: caution in patients volume and/or sodium depleted by vigorous diuretic therapy, dietary salt restriction, diarrhea or vomiting
- Caution in renal artery stenosis, aortic or mitral stenosis, obstructive hypertrophic cardiomyopathy
- Contraindicated in pregnancy and lactation
Overdose effects
Overdose: Doses up to 900 mg/day for 8 weeks revealed no toxicity; most likely manifestations: hypotension and tachycardia; bradycardia may also occur; induction of emesis and/or gastric lavage; activated charcoal may be useful; not removed by haemodialysis.
Storage conditions
Store in a cool and dry place, protected from light.