৳ 210/unit
Pack: ৳ 210
৳ 210/unit
Pack: ৳ 210
At a glance
Cefdinir is a third-generation oral cephalosporin antibiotic used in the treatment of community-acquired pneumonia, acute exacerbations of chronic bronchitis, acute maxillary sinusitis, pharyngitis/tonsillitis, acute bacterial otitis media, and uncomplicated skin and skin structure infections. It kills bacteria by inhibiting bacterial cell wall synthesis.
Indications
- Community-acquired pneumonia
- Acute exacerbations of chronic bronchitis
- Acute maxillary sinusitis
- Pharyngitis/tonsillitis
- Acute bacterial otitis media
- Uncomplicated skin and skin structure infections
Pharmacology
Cefdinir is a semisynthetic third-generation oral cephalosporin antibiotic with broad-spectrum bactericidal activity against common pathogens, including β-lactamase-producing strains. As with other cephalosporins, its bactericidal activity results from inhibition of cell wall synthesis.
Dosage
Adults (Total daily dose 600 mg for all infections):
• Acute exacerbations of chronic bronchitis: 300 mg twice daily OR 600 mg once daily (5-10 days)
• Pharyngitis/Tonsillitis: 300 mg twice daily OR 600 mg once daily (10 days)
• Acute bacterial otitis media: 300 mg twice daily OR 600 mg once daily (10 days)
• Acute maxillary sinusitis: 300 mg twice daily OR 600 mg once daily (10 days)
• Community-acquired pneumonia: 300 mg twice daily (10 days)
• Uncomplicated skin and skin structure infections: 300 mg twice daily (10 days)
Children (Suspension, total daily dose 14 mg/kg, max 600 mg/day):
• Acute bacterial otitis media: 7 mg/kg twice daily OR 14 mg/kg once daily (5-10 days)
• Pharyngitis/Tonsillitis: 7 mg/kg twice daily OR 14 mg/kg once daily (10 days)
• Acute maxillary sinusitis: 7 mg/kg twice daily OR 14 mg/kg once daily (10 days)
• Uncomplicated skin and skin structure infections: 7 mg/kg twice daily (10 days)
Renal impairment (CrCl <30 mL/min): 300 mg once daily
Hepatic impairment: No dosage adjustment needed.
Side effects
Common side effects: Diarrhea, vaginal moniliasis, nausea, vomiting, headache, rash.
Iron supplements may cause reddish stools (harmless).
Use in pregnancy
Generally considered safe during pregnancy (Category B). Animal studies have shown low or no adverse effects; limited human studies available. Use during pregnancy only if clearly needed.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Prescribing in the absence of proven bacterial infection is unlikely to provide benefit and increases the risk of drug-resistant bacteria.
- Caution in patients with history of colitis.
- If rash, itching, swelling of face/mouth, or difficulty breathing occurs, discontinue and inform your doctor.
- Severe and persistent diarrhea may indicate pseudomembranous colitis.
- Dose adjustment required in renal impairment (CrCl <30 mL/min: 300 mg/day).
- Allow at least 2 hours between antacids/iron supplements and cefdinir.
- Avoid alcohol consumption (may increase side effects).
Overdose effects
Overdose symptoms: Nausea, vomiting, diarrhea. Treatment: Supportive and symptomatic.
Storage conditions
Store at room temperature, protected from light. After reconstitution, suspension can be used for 7 days at room temperature and 14 days in the refrigerator (2-8°C). Keep the bottle tightly closed.