৳ 1/unit
Pack: ৳ 1
৳ 1/unit
Pack: ৳ 1
At a glance
Cefpodoxime is a third generation cephalosporin antibiotic used to treat bacterial infections of the lungs, urinary tract, ear, nasal sinus, throat, and skin.
Indications
- Acute Otitis Media
- Pharyngitis/Tonsillitis
- Acute Maxillary Sinusitis
- Community Acquired Pneumonia
- Acute Bacterial Exacerbation of Chronic Bronchitis
- Skin and Skin Structure Infections
- Uncomplicated Urinary Tract Infections
- Uncomplicated Gonorrhea
Pharmacology
Cefpodoxime is an oral 3rd generation cephalosporin, which has good stability to beta lactamases and activity against Gram negative and Gram positive bacteria. It is indicated for the treatment of infections either before the infecting organism has been identified. It is a prodrug whose active metabolite is Cefpodoxime. Approximately 29 to 33% of Cefpodoxime is excreted unchanged in the urine in 12 hours.
Cefpodoxime is indicated for the treatment of patients infected with susceptible strains of microorganisms which include a wide range of gram-positive & gram-negative bacteria. As it is highly stable in presence of β-lactamase enzyme, so it is more effective against gram-positive bacteria than other 3rd generation oral cephalosporins.
Dosage
Adult Dose:
| Infection Type | Dose | Schedule | Duration |
|---|---|---|---|
| Acute Bronchitis, Acute Sinusitis | 200 mg | 12 hourly | 10 days |
| Community-Acquired Pneumonia | 200 mg | 12 hourly | 14 days |
| Pharyngitis/Tonsillitis | 100 mg | 12 hourly | 5-10 days |
| Skin Infections | 400 mg | 12 hourly | 7-14 days |
| Uncomplicated UTI | 100 mg | 12 hourly | 7-14 days |
| Uncomplicated Gonorrhea | 200 mg | Single dose | — |
Pediatric Dose (2 months-12 years):
| Age | Dose | Schedule |
|---|---|---|
| 6 months-2 years | 40 mg | 12 hourly |
| 3-8 years | 80 mg | 12 hourly |
| Over 9 years | 100 mg | 12 hourly |
| Weight-based | 10 mg/kg/day (max 400 mg/day) | 12 hourly |
Renal Dose:
| Creatinine Clearance (ml/min) | Dose Adjustment |
|---|---|
| 10-39 | Increase dosing intervals to 24 hourly |
| <10 | Increase dosing intervals to 48 hourly |
Hemodialysis patients: Dose should be given after each dialysis session.
Hepatic impairment: Dose adjustment not necessary.
Side effects
Common Side Effects:
- Rash
- Nausea
- Diarrhea
- Vomiting
- Abdominal pain
- Headache
- Dizziness
Use in pregnancy
[SAFE IF PRESCRIBED] Cefpodoxime is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. Pregnancy Category B. This drug should be used during pregnancy only if clearly needed.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- [UNSAFE] Cefpodoxime may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
- Your doctor has prescribed Cefpodoxime to cure your infection and improve your symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
- Discontinue Cefpodoxime and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
- Take it with food to avoid an upset stomach.
- Avoid consuming alcohol while taking Cefpodoxime as it may cause increased side effects.
- As with other broad spectrum antibiotics, prolonged use of Cefpodoxime may result in overgrowth of non-susceptible organisms. Repeated evaluation of the patient's condition is essential.
Overdose effects
Information on Cefpodoxime overdosage is not available.
Storage conditions
Keep in a dry place away from light and heat. Keep out of the reach of children. The reconstituted suspension should be stored in a cool and dry place, preferably in refrigerator and unused portion should be discarded after 14 days.