৳ 38.14/unit
Pack: ৳ 38.14
৳ 38.14/unit
Pack: ৳ 38.14
At a glance
Cefaclor is a second-generation cephalosporin antibiotic used in the treatment of various bacterial infections. It kills bacteria by inhibiting bacterial cell wall synthesis.
Indications
- Respiratory tract infections (pneumonia, bronchitis)
- Otitis media
- Pharyngitis and tonsillitis
- Urinary tract infections (pyelonephritis, cystitis)
- Skin and skin structure infections
Pharmacology
Cefaclor is a second-generation cephalosporin antibiotic which has stability against β-lactamase inactivation and possesses a broad spectrum of activity. It inhibits the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall, inhibiting biosynthesis and arresting cell wall assembly, resulting in bacterial cell death.
Dosage
Adults: 250-500 mg every 8 hours (oral). Severe infections: up to 4 g/day. β-hemolytic Streptococcal infections: at least 10 days of therapy.
Children (>1 month): 20 mg/kg/day in divided doses every 8 hours. Severe infections (e.g., otitis media): 40 mg/kg/day (max 1 g/day).
Pediatric dosing table:
1 month-1 year (9 kg): Suspension ½ tsp tid; Pediatric drops 0.625 ml tid
1-5 years (9-18 kg): Suspension 1 tsp tid; Pediatric drops 1.25 ml tid
Over 5 years: Suspension 2 tsp tid
Renal impairment: CrCl 10-50 mL/min: Half to full dose; CrCl <10 mL/min: Half dose.
Hemodialysis: Predialysis loading dose: 250 mg-1 g; Interdialytic maintenance: 250-500 mg every 6 hours.
Elderly: No differences in responses observed compared to younger patients.
Infants <1 month: Safety and efficacy not established.
Side effects
Common side effects: Rash, vomiting, allergic reaction, nausea, injection site reaction, increased liver enzymes, diarrhea.
Gastrointestinal: Diarrhea, nausea, vomiting.
Rare: Transient hepatitis, cholestatic jaundice, fever, abdominal pain, superinfection, renal dysfunction, toxic nephropathy, hemorrhage, elevated LDH, pancytopenia.
Side effects are usually mild and transient.
Use in pregnancy
Generally considered safe during pregnancy (Category B). Animal studies have shown low or no adverse effects; limited human studies available. Use during pregnancy only if clearly needed.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Prescribing in the absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit and increases the risk of drug-resistant bacteria.
- Prolonged use may result in overgrowth of nonsusceptible organisms; if superinfection occurs, take appropriate measures.
- Use with caution in penicillin-sensitive patients (risk of cross-allergy).
- Use with caution in patients with history of gastrointestinal disease, particularly colitis.
- If rash, itching, swelling of face/mouth, or difficulty breathing occurs, discontinue and inform your doctor.
- If diarrhea does not stop or if blood is found in stools, inform your doctor.
- Avoid alcohol consumption (may increase side effects).
Overdose effects
Overdose symptoms: Nausea, vomiting, epigastric distress, diarrhea. Treatment: Supportive and symptomatic.
Storage conditions
Store at room temperature, protected from light. After reconstitution, suspension can be used for 7 days at room temperature and 14 days in the refrigerator (2-8°C). Keep the bottle tightly closed.