৳ 64/unit
Pack: ৳ 640
৳ 64/unit
Pack: ৳ 640
At a glance
Cenobamate is an anti-epileptic drug used for the treatment of partial-onset seizures in adult patients.
Indications
- Partial-onset seizures in adult patients
Pharmacology
Cenobamate is a positive GABA-A modulator which inhibits voltage-gated sodium channels. Inhibition of voltage-gated sodium channels increases the threshold for generating action potentials and decreases the number of action potentials. Its dual, complementary mechanisms of action may contribute to superior anti-seizure activity.
Dosage
Recommended Dosage for Partial-Onset Seizures in Adults:
| Week | Daily Dose |
|---|---|
| Week 1 and 2 | 12.5 mg once daily |
| Week 3 and 4 | 25 mg once daily |
| Week 5 and 6 | 50 mg once daily |
| Week 7 and 8 | 100 mg once daily |
| Week 9 and 10 | 150 mg once daily |
| Week 11 and thereafter (Maintenance) | 200 mg once daily |
Maximum Dosage: If needed based on clinical response and tolerability, the dose may be increased above 200 mg by increments of 50 mg once daily every two weeks to 400 mg once daily.
Renal Dose: Use with caution in mild to severe renal impairment (CrCl 30-90 or <30); consider dose reduction; maximum 300 mg/day. Not recommended in end-stage renal disease or hemodialysis.
Hepatic Dose: Use with caution in mild to moderate hepatic impairment; consider dose reduction; not recommended in severe hepatic impairment.
Side effects
Common Side Effects:
- Somnolence
- Fatigue
- Dizziness
- Nausea
- Constipation
- Double vision
- Decreased appetite
- Diarrhea
- Weakness
Rare: A very serious allergic reaction to this drug is rare.
Use in pregnancy
There are no adequate and well-controlled studies in pregnant women with the use of Cenobamate. But it may cause fetal harm when administered to a pregnant woman. It should be used during pregnancy only if the potential benefits justify the potential risk to the fetus.
Precautions & warnings
- Potential adverse effects such as Multiorgan hypersensitivity reaction (DRESS), QT shortening, and Suicidal thoughts.
- Somnolence and fatigue should be periodically re-evaluated.
- Patients are advised not to drive or operate machinery during cenobamate therapeutic regimen.
- Cenobamate should be gradually withdrawn to minimize the potential of increased seizure frequency.
- Concomitant use with other CNS depressants or alcohol may have additive effects.
- Monitor patients for suicidal behavior and ideation.
Overdose effects
In the event of overdose, Cenobamate should be discontinued and general supportive treatment given until clinical toxicity has been diminished or resolved.
Storage conditions
Do not store above 30°C. Keep away from light and out of the reach of children.