Cerinib150mg
Rx- Generic:
- Ceritinib
- Company:
- Drug International Ltd.
- Dosage form:
- Capsule
- Pack size:
- Box (30 Capsule)
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৳ 626.67/unit
Pack: ৳ 18,800.10
At a glance
Ceritinib is a kinase inhibitor indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive.
Indications
- ALK-positive metastatic non-small cell lung cancer (NSCLC)
Dosage
Recommended Dose: 450 mg orally once daily with food until disease progression or unacceptable toxicity.
Hepatic Dose: Severe hepatic impairment (Child-Pugh C): Reduce dose by approximately one-third, rounded to the nearest multiple of the 150 mg dosage strength. No dose adjustment is recommended in patients with mild (Child-Pugh A) or moderate (Child-Pugh B) hepatic impairment.
Side effects
Common Side Effects (≥10%):
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Elevated liver enzymes (ALT/AST)
- Hyperglycemia
- Bradycardia
- Pancreatitis
Serious Side Effects: Interstitial Lung Disease/Pneumonitis, QT Prolongation, Hepatotoxicity.
Precautions & warnings
- Gastrointestinal Reactions: Monitor and manage diarrhea, nausea, vomiting, or abdominal pain with standard care.
- Hepatotoxicity: Monitor liver function tests (ALT, AST, total bilirubin) once a month and as clinically indicated.
- Interstitial Lung Disease/Pneumonitis: Monitor for pulmonary symptoms.
- QT Prolongation: Avoid in congenital long QT syndrome; monitor with ECGs and electrolytes.
- Hyperglycemia: Monitor fasting serum glucose.
- Bradycardia: Regularly monitor heart rate and blood pressure.
- Pancreatitis: Monitor lipase and amylase.
- Embryo-Fetal Toxicity: Can cause fetal harm; advise effective contraception.
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.