৳ 60.18/unit
Pack: ৳ 240.72
৳ 60.18/unit
Pack: ৳ 240.72
At a glance
Tadalafil is a PDE5 inhibitor used for erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and combined ED+BPH. It increases blood flow by inhibiting PDE5 and raising cGMP in the corpus cavernosum.
Indications
- Erectile Dysfunction (ED)
- Benign Prostatic Hyperplasia (BPH)
- Both ED and BPH symptoms
Pharmacology
Tadalafil inhibits PDE5, increasing cGMP in smooth muscle cells of the corpus cavernosum, causing smooth muscle relaxation and increased blood flow for erection. In the prostate and bladder, PDE5 inhibition relaxes smooth muscle, improving blood flow and widening the bladder neck for better voiding.
Dosage
Adult Dose (Oral):
- ED (as needed): Start 10 mg; adjust 5-20 mg based on need; max once daily
- ED (daily): Start 2.5 mg/day; may increase to 5 mg/day
- BPH: 5 mg/day (same time each day)
- ED+BPH: 5 mg/day
- Hepatic impairment (ED): Mild-moderate: max 10 mg/day; severe: do not use
Side effects
Common Side Effects:
- Headache, dyspepsia
- Back pain, myalgia
- Nasopharyngitis, nasal congestion
Rare:
- Vision changes, sudden vision loss
- Hearing loss
- Stevens-Johnson syndrome
- Angina, stroke, MI
Use in pregnancy
Use in Pregnancy: Generally safe; animal studies show low or no adverse effects; limited human data; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not use with nitrates (isosorbide, nitroglycerin) – severe hypotension
- Recent MI (within 90 days) or stroke (within 6 months)
- Uncontrolled hypertension, uncontrolled arrhythmias
- Caution in severe hepatic or renal impairment
Overdose effects
Overdose may increase side effects; provide symptomatic treatment; do not use nitrates.
Storage conditions
Store in a dry place, away from light and heat; keep out of reach of children.