৳ 1,195/unit
Pack: ৳ 1,195
৳ 1,195/unit
Pack: ৳ 1,195
At a glance
Imipenem + Cilastatin is an antibiotic combination used for the treatment of serious bacterial infections including lower respiratory tract, urinary tract, intra-abdominal, gynecologic infections, bacterial septicemia, bone and joint infections, skin and skin structure infections, and endocarditis.
Indications
- Lower respiratory tract infections
- Urinary tract infections
- Intra-abdominal infections
- Gynecologic infections
- Bacterial septicemia
- Bone and joint infections
- Skin and skin structure infections
- Endocarditis
Pharmacology
Imipenem is a penem antibacterial with bactericidal activity resulting from inhibition of cell wall synthesis. It shows greatest affinity for penicillin-binding proteins (PBPs) 1A, 1B, 2, 4, 5 and 6. Imipenem has high stability in the presence of beta-lactamases. Cilastatin inhibits renal dehydropeptidase I to limit the renal metabolism of imipenem and protect against nephrotoxic effects.
Dosage
Adult Dose (IV):
- General (CrCl ≥90 mL/min): 500 mg every 6 hours OR 1000 mg every 8 hours OR 1000 mg every 6 hours
- Mild to moderate infections: 500-750 mg IV every 12 hours
- Intra-abdominal: 250-500 mg IV every 6 hours (severe: 500 mg q6h or 1 g q8h)
- Urinary tract: Uncomplicated: 250 mg q6h; Complicated: 500 mg q6h
- Max daily dose: 50 mg/kg/day or 4 g/day (whichever is lower)
Child Dose (IV):
- ≥3 months: 15-25 mg/kg every 6 hours
- ≤3 months (≥1500 g): 4 wks-3 mo: 25 mg/kg q6h; 1-4 wks: 25 mg/kg q8h; <1 wk: 25 mg/kg q12h
Renal Dose: CrCl 31-70: 500 mg q6-8h; 21-30: 500 mg q8-12h; 6-20: 250 mg q12h; <5: Only if hemodialysis started within 48 hr
Side effects
Common Side Effects:
- Phlebitis
- Nausea
- Diarrhea
- Vomiting
- Rash
- Pruritus
- Urticaria
- Pain at injection site, erythema
- Fever
- Hypotension
- Seizures
- Dizziness
- Somnolence
Use in pregnancy
Use in Pregnancy: Category C; no adequate and well-controlled studies in pregnant women; use only if potential benefit justifies potential risk to mother and fetus.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Imipenem + Cilastatin may affect your ability to drive (seizures, dizziness, somnolence)
- Serious and occasionally fatal anaphylactic reactions reported; discontinue if allergy occurs
- Seizures and other CNS adverse reactions reported; if focal tremors, myoclonus or seizures occur, evaluate neurologically
- Caution or avoid in penicillin allergy
- Monitor liver and kidney function
Overdose effects
Overdose: May cause seizures, CNS toxicity, nausea, vomiting, diarrhea; provide symptomatic supportive treatment; hemodialysis may be effective.
Storage conditions
Store at or below 25°C; keep away from light and wet place; keep out of reach of children.