৳ 10/unit
Pack: ৳ 10
৳ 10/unit
Pack: ৳ 10
At a glance
Calcitriol + Calcium is a combination tablet used in the treatment of osteoporosis, hypoparathyroidism, hypocalcaemia, osteomalacia, rickets, renal osteodystrophy, and chronic kidney dialysis. It replenishes calcium deficiency and improves bone health.
Indications
- Osteoporosis
- Hypoparathyroidism
- Hypocalcaemia
- Osteomalacia
- Rickets
- Renal osteodystrophy
- Chronic kidney dialysis
Pharmacology
Calcium citrate is a good source of calcium that is well absorbed on an empty stomach and does not cause constipation. Calcitriol is the active form of vitamin D3 that increases intestinal calcium and phosphate absorption and regulates bone mineralization. The biological effects of calcitriol are mediated by the vitamin D receptor, functioning as a ligand-activated transcription factor that modifies expression of target genes.
Dosage
Adults: 1-4 tablets daily (depending on clinical condition), with or without food, or as directed by the registered physician.
Hyperparathyroidism in renal failure: 0.25 mcg/day or alternate day; may increase slowly.
Hypoparathyroidism/Pseudohypoparathyroidism: 0.5-2 mcg once daily.
Vitamin D-dependent rickets: 0.015-0.02 mcg/kg/day (initial); 0.03-0.06 mcg/kg/day (maintenance). Max: 2 mcg/day.
Note: Dose must be individualized based on serum calcium levels.
Side effects
Calcium-related side effects: Anorexia, constipation, flatulence, nausea, vomiting, hypercalcemia, hypophosphatemia, xerostomia, acid rebound, milk-alkali syndrome, coma, confusion, delirium, headache, lethargy.
Calcitriol-related side effects: Abdominal pain, apathy, increased BUN/creatinine, cardiac arrhythmia, constipation, dry mouth, dehydration, growth suppression, headache, hyperthermia, hypercalcemia, hypercholesterolemia, hypermagnesemia, hyperphosphatemia, hypertension, decreased libido, metallic taste, muscle/bone pain, nocturia, pruritus, psychosis, somnolence, weakness.
Use in pregnancy
May be unsafe during pregnancy (Category C). Use only as directed by a registered physician during pregnancy.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in idiopathic hypercalcemia.
- Caution in coronary disease, renal impairment, and arteriosclerosis (especially in elderly).
- Caution in hypoparathyroidism.
- Pediatric doses must be individualized and monitored under close medical supervision.
- Caution in hypercalcemia, malabsorption syndrome, heart disease, kidney disease, kidney stones, sarcoidosis, liver disease, Crohn's disease.
- Risk of hypercalcemia with thiazide diuretics or excessive vitamin D.
Overdose effects
Overdose may cause hypercalcemia, hypercalciuria, hyperphosphatemia, milk-alkali syndrome. Symptoms: nausea, vomiting, constipation, confusion, coma. Consult your doctor immediately if overdose is suspected.
Storage conditions
Store in a cool and dry place below 25°C, protected from light and moisture. Keep out of reach of children.