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Amoxicillin + Clavulanic Acid (Clavulanate) is a penicillin-type of antibiotic that helps your body fight infections caused by bacteria. It is used to treat infections of the lungs (e.g., pneumonia), ear, nasal sinus, urinary tract, skin and soft tissue. It will not work for viral infections such as the common cold. Amoxicillin + Clavulanic Acid (Clavulanate) is best taken with a meal to reduce the chance of a stomach upset. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being treated for, but you should always complete a full course of this antibiotic as prescribed by your doctor. Do not stop taking it until you have finished, even when you feel better. If you stop taking it early, some bacteria may survive and the infection may come back or worsen. The most common side effects of this medicine include vomiting, nausea, and diarrhea. These are usually mild but let your doctor know if they bother you or will not go away. Before taking it, let your doctor know if you are allergic to any antibiotics or have any kidney or liver problems. You should also let your healthcare team know about all other medicines you are taking as they may affect, or be affected by, this medicine. This medicine is generally regarded as safe to use during pregnancy and breastfeeding if prescribed by a doctor. Amoxicillin + Clavulanic Acid (Clavulanate) is a combination of two medicines: Amoxycillin and Clavulanic Acid. Amoxycillin is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Clavulanic Acid is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Amoxycillin against bacteria.

• Bacterial infections

Take with meals to avoid GI upset Take suspension at start of meal to enhance absorption Reconstitution: Powd for inj: Dissolve amoxicillin/clavulanic acid 500/100 mg in 10 mL solvent and 1,000/200 mg in 20 mL solvent. May further dilute to infusion soln containing either water for inj or NaCl 0.9%.

Adult Dose: History of allergy especially to cephalosporins, infectious mononucleosis, severe renal impairment. Lactation: Drug excreted in breast milk; use caution Renal Dose: Clavulanic acid has a high affinity for and binds to certain ?-lactamases that generally inactivate amoxicillin by hydrolyzing its ?-lactam ring. Combining clavulanate potassium with amoxicillin extends the antibacterial spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin and other penicillins and cephalosporins.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Amoxicillin + Clavulanic Acid (Clavulanate) is to be taken with food.

If you miss a dose of Amoxicillin + Clavulanic Acid (Clavulanate), take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Vomiting • Nausea • Diarrhea

[UNSAFE] Amoxicillin + Clavulanic Acid (Clavulanate) may cause side effects which could affect your ability to drive. Amoxicillin + Clavulanic Acid (Clavulanate) may cause side effects such as allergic reactions, dizziness or fits that may make you unfit to drive. You have been prescribed this combination medicine to treat bacterial infections even if they have developed resistance. Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat. Diarrhea may occur as a side effect. Taking probiotics along with Amoxicillin + Clavulanic Acid (Clavulanate) may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps. Take it with food and plenty of fluids to avoid an upset stomach. Stop taking Amoxicillin + Clavulanic Acid (Clavulanate) and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it. Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic.

Children: 125/31.25-, 250/62.5-mg/5-mL susp: 20–40 mg amoxicillin component/kg/day (max 1,500 mg/day) q8h 200/28.5-, 400/57-mg/5-mL susp: 25-45 mg amoxicillin component/kg/day (max 1,750 mg/day) q12h Children of 6-12 years: 2 teaspoonful Powder for Suspension every 8 hours. Children of 1-6 years: 1 teaspoonful Powder for Suspension every 8 hours. Children below 1 year: 25 mg/kg/day in divided doses every 8 hours. Children over 12 years: IV Injection: 1.2 g every 6-8 hours, Children up to 3 months: 30 mg/kg every 8 hours (every 12 hours in the perinatal period and in premature infants); Child 3 months-12 years, 30 mg/kg every 6-8 hours.

Penicillin allergy.

[SAFE] Consuming alcohol with Amoxicillin + Clavulanic Acid (Clavulanate) does not cause any harmful side effects.

[SAFE IF PRESCRIBED] Amoxicillin + Clavulanic Acid (Clavulanate) is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Amoxicillin + Clavulanic Acid (Clavulanate) is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

[CAUTION] Amoxicillin + Clavulanic Acid (Clavulanate) should be used with caution in patients with kidney disease. Dose adjustment of Amoxicillin + Clavulanic Acid (Clavulanate) may be needed. Please consult your doctor. Use of this medicine is not recommended in patients with severe kidney disease. [CAUTION] Amoxicillin + Clavulanic Acid (Clavulanate) should be used with caution in patients with liver disease. Dose adjustment of Amoxicillin + Clavulanic Acid (Clavulanate) may be needed. Please consult your doctor. Regular monitoring of liver function tests is recommended while you are taking this medicine

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