৳ 25/unit
Pack: ৳ 175
৳ 25/unit
Pack: ৳ 175
At a glance
Cefpodoxime + Clavulanic Acid is a combination of two medicines used to treat respiratory tract bacterial infections and prevents further growth and spread of microorganisms.
Indications
- Acute bacterial exacerbation of chronic bronchitis
- Acute community acquired pneumonia
- Pharyngitis or tonsillitis
- Skin and soft tissue infections
- Urinary tract infections
- Uncomplicated gonorrhea
- Acute maxillary sinusitis
Pharmacology
Cefpodoxime is a third generation semi-synthetic Cephalosporin, exhibits activity against several Gram positive as well as Gram negative microorganisms. This compound is also stable in beta lactamase environment. Cefpodoxime exhibits exceptional activity against methicillin susceptible Staphylococci, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria spp. and Moraxella catarrhalis.
Clavulanic acid is a natural inhibitor of beta lactamase which are produced by Streptomyces clavuligerus. It binds to beta lactamase moieties and inactivates them, thus restricting the Cefpodoxime destruction.
Dosage
Adult Dose (12 years and older):
| Infection Type | Dose | Schedule | Duration |
|---|---|---|---|
| Acute Bronchitis, Acute Sinusitis | 200 mg (1 tablet) | 12 hourly | 10 days |
| Community-Acquired Pneumonia | 200 mg (1 tablet) | 12 hourly | 14 days |
| Pharyngitis/Tonsillitis | 100 mg (1/2 tablet) | 12 hourly | 5-10 days |
| Skin & Soft Tissue Infections | 200-400 mg (1-2 tablets) | 12 hourly | 7-14 days |
| Uncomplicated UTI | 100 mg (1/2 tablet) | 12 hourly | 7 days |
| Complicated UTI | 200 mg (1 tablet) | 12 hourly | 7 days |
| Uncomplicated Gonorrhea | 200 mg | Single dose | — |
Pediatric Dose (2 months-12 years): 10 mg/kg/day, 12 hourly (max 400 mg/day).
| Age | Dose | Schedule |
|---|---|---|
| 6 months-2 years | 40 mg | 12 hourly |
| 3-8 years | 80 mg | 12 hourly |
| Over 9 years | 100 mg | 12 hourly |
Renal Dose:
| Creatinine Clearance (ml/min) | Dose Adjustment |
|---|---|
| 10-39 | Increase dosing intervals to 24 hourly |
| <10 | Increase dosing intervals to 48 hourly |
Hemodialysis patients: Dose should be given after each dialysis session.
Hepatic impairment: Dose adjustment not necessary.
Side effects
Common Side Effects:
- Nausea
- Diarrhea
- Stomach pain
- Headache
- Vomiting
- Indigestion
Use in pregnancy
[SAFE IF PRESCRIBED] Cefpodoxime + Clavulanic Acid is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. Pregnancy Category B. This drug should be used during pregnancy only if clearly needed.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- [UNSAFE] Cefpodoxime + Clavulanic Acid may cause side effects which could affect your ability to drive. Allergic reactions, dizziness or fits may make you unfit to drive.
- You have been prescribed this combination medicine to treat bacterial infections even if they have developed resistance.
- Take it with food and plenty of fluids to avoid an upset stomach.
- Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
- Diarrhea may occur as a side effect. Taking probiotics along with it may help.
- Talk to your doctor if you notice bloody stools or develop abdominal cramps.
- Stop taking it and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.
- Cefpodoxime should be administered with caution to patients receiving concurrent treatment with diuretics.
Overdose effects
Information on Cefpodoxime + Clavulanic Acid overdosage is not available.
Storage conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.