osudhkosh
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Company•Opsonin Pharma Limited

Clinorel 200

Rx
Generic: Sulindac

৳ 9.54/unit

Pack: ৳ 95.40

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At a glance

Sulindac is an NSAID used for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gouty arthritis, and acute painful shoulder.

Indications
  • Rheumatoid arthritis
  • Osteoarthritis
  • Ankylosing spondylitis
  • Periarticular inflammatory disorders
  • Acute painful shoulder
  • Acute gouty arthritis
  • Diabetic neuropathy
  • Diabetic retinopathy
Pharmacology

Sulindac is a prodrug that is metabolized in the liver to its active sulfide metabolite. This active metabolite inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis and decreasing inflammation, pain, and fever.

Dosage

Adult Dose (Oral):

  • Osteoarthritis/RA/Ankylosing spondylitis: 150 mg twice daily; max 400 mg/day
  • Acute painful shoulder/Acute gouty arthritis: 200 mg twice daily (7-14 days); max 400 mg/day
Side effects

Common Side Effects (1-10%):

  • Abdominal pain (10%), constipation (3-9%)
  • Diarrhea (3-9%), dizziness (3-9%)
  • Dyspepsia (3-9%), headache (3-9%)
  • Nausea (3-9%), rash (3-9%)

Serious (<1%):

  • Hypersensitivity reactions, thrombocytopenia
  • Leukopenia, agranulocytosis
  • Hematuria, renal impairment
  • Hepatitis, jaundice, liver necrosis
Use in pregnancy

Use in Pregnancy: First two trimesters (Category C): use only if clearly needed; 3rd trimester (Category D): do not use; consult your doctor.

Pregnancy Category: D — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Use at lowest effective dose for the shortest duration possible
  • Risk of serious cardiovascular thrombotic events, MI, and stroke
  • May cause hypertension, fluid retention, and edema; caution in heart failure
  • Serious GI adverse events (ulceration, bleeding, perforation) may occur
  • Severe hepatotoxicity (jaundice, fulminant hepatitis) is rare
  • May cause renal impairment; higher risk in pre-existing renal disease, heart failure, elderly
Overdose effects

Overdose may cause GI, renal, and CNS toxicity; provide symptomatic and supportive treatment.

Storage conditions

Store below 25°C, away from light and moisture; keep out of reach of children.

Sulindac — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.